Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jul 11;40(7):701-702.
doi: 10.1016/j.ccell.2022.05.016. Epub 2022 Jun 16.

The local microenvironment matters in preclinical basic and translational studies of cancer immunology and immunotherapy

Affiliations

The local microenvironment matters in preclinical basic and translational studies of cancer immunology and immunotherapy

William W Ho et al. Cancer Cell. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Declaration of interests R.K.J. received consultant fees from Elpis, Innocoll, SPARC, SynDevRx; owns equity in Accurius, Enlight, SynDevRx; serves in Board of Trustees of Tekla Healthcare Investors, Tekla Life Sciences Investors, Tekla Healthcare Opportunities Fund, and Tekla World Healthcare Fund; and received a research grant from Boehringer Ingelheim. M.J.P. has been a consultant for Acthera, Aileron Therapeutics, AstraZeneca, Cygnal Therapeutics, Debiopharm, Elstar Therapeutics, ImmuneOncia, KSQ Therapeutics, Merck, Siamab Therapeutics, Third Rock Ventures, and Tidal. All other authors declare no competing interests. No funding or reagents from these organizations were used in this study.

References

    1. Amoozgar Z, Kloepper J, Ren J, Tay RE, Kazer SW, Kiner E, Krishnan S, Posada JM, Ghosh M, Mamessier E, et al. (2021). Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas. Nat. Commun 12, 2582. 10.1038/s41467-021-22885-8. - DOI - PMC - PubMed
    1. Day C-P, Pérez-Guijarro E, Lopès A, Goldszmid RS, Murgai M, Wakefield L, and Merlino G (2022). Recognition of observer effect is required for rigor and reproducibility of preclinical animal studies. Cancer Cell 40, 231–232. 10.1016/j.ccell.2022.01.015. - DOI - PubMed
    1. Fukumura D, Yuan F, Monsky WL, Chen Y, and Jain RK (1997). Effect of host microenvironment on the microcirculation of human colon adenocarcinoma. Am. J. Pathol 151, 679–688. - PMC - PubMed
    1. Grzelak CA, Goddard ET, Lederer EE, Rajaram K, Dai J, Shor RE, Lim AR, Kim J , Beronja S, Funnell APW, and Ghajar CM (2022). Elimination of fluorescent protein immunogenicity permits modeling of metastasis in immune-competent settings. Cancer Cell 40, 1–2. 10.1016/j.ccell.2021.11.004. - DOI - PMC - PubMed
    1. Guerin MV, Regnier F, Feuillet V, Vimeux L, Weiss JM, Bismuth G, Altan-Bonnet G, Guilbert T, Thoreau M, Finisguerra V, et al. (2019). TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors. Nat. Commun 10, 4131. 10.1038/s41467-019-11998-w. - DOI - PMC - PubMed

Substances