Reproductive Organ Pathology of Individuals Undergoing Gender-Affirming Surgery

Abstract

As gender-affirming surgeries become more routine, it is increasingly important for pathologists to recognize the expected histologic changes seen in various tissues secondary to gender-affirming hormone therapy. For example, exogenous testosterone-related squamous atrophy or transitional cell metaplasia of the cervix may be confused for high-grade squamous intraepithelial lesion. In addition to distinguishing between benign and dysplastic/malignant features, pathologists should be mindful of the phrasing of their reports and aim to use objective, nongendered language.

Keywords: Exogenous estrogen; Exogenous testosterone; Gender-affirming surgery; Transgender.