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Meta-Analysis
. 2023 Mar;19(3):831-843.
doi: 10.1002/alz.12695. Epub 2022 Jun 17.

Global incidence of young-onset dementia: A systematic review and meta-analysis

Stevie Hendriks  1 , Kirsten Peetoom  1 , Christian Bakker  2   3 , Raymond Koopmans  2 , Wiesje van der Flier  4 , Janne Papma  5 , Frans Verhey  1 ; Young‐Onset Dementia Epidemiology Study Group; Marjolein de Vugt  1 , Sebastian Köhler  1
Affiliations
Meta-Analysis

Global incidence of young-onset dementia: A systematic review and meta-analysis

Stevie Hendriks et al. Alzheimers Dement. 2023 Mar.

Abstract

Introduction: Reliable data on the incidence rates for young-onset dementia (YOD) are lacking, but are necessary for research on disease etiology and to raise awareness among health care professionals.

Methods: We performed a systematic review and meta-analysis on population-based studies on the incidence of YOD, published between January 1, 1990 and February 1, 2022, according to Meta-analyses of Observational Studies in Epidemiology (MOOSE) guidelines. Data were analyzed using random-effects meta-analyses. Results were age-standardized, and heterogeneity was assessed by subgroup analyses and meta-regression.

Results: Sixty-one articles were included. Global age-standardized incidence rates increased from 0.17/100,000 in age 30 to 34 years, to 5.14/100,000 in age 60 to 64 years, giving a global total age-standardized incidence rate of 11 per 100,000 in age 30 to 64. This corresponds to 370,000 new YOD cases annually worldwide. Heterogeneity was high and meta-regression showed geographic location significantly influenced this heterogeneity.

Discussion: This meta-analysis shows the current best estimate of YOD incidence. New prospective cohort studies are needed.

Keywords: incidence; meta‐analysis; worldwide; young‐onset dementia.

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References

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