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. 2023 Mar;19(3):857-867.
doi: 10.1002/alz.12704. Epub 2022 Jun 17.

Trajectories of cognitive decline and dementia development: A 12-year longitudinal study

Nicola M Payton  1   2 , Anna Marseglia  1   2 , Giulia Grande  1 , Laura Fratiglioni  1   3 , Miia Kivipelto  2   4   5   6   7 , Lars Bäckman  1 , Erika J Laukka  1   3
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Trajectories of cognitive decline and dementia development: A 12-year longitudinal study

Nicola M Payton et al. Alzheimers Dement. 2023 Mar.

Abstract

Introduction: Mapping the preclinical dementia phase is important for early detection and evaluation of interventions. We assessed the trajectories of cognitive decline in preclinical dementia over 12 years and investigated whether being a fast decliner across 6 years is associated with increased risk of dementia the following 6 years.

Methods: Rates of cognitive decline were determined using mixed-effects models for 1646 participants from the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K) cohort. Cox regression was used to assess the future likelihood of dementia for fast decliners (declining ≥1.5 standard deviations [SDs] faster than the age-specific rates).

Results: Participants in a preclinical phase of dementia showed increased rates of decline in all cognitive tests compared to the no-dementia group, particularly closer (0-6 years) to diagnosis. Participants declining fast in three or more cognitive tests 12-6 years before diagnosis demonstrated a high risk of dementia 6 years later (hazard ratio [HR] 3.90, 95% confidence interval [CI] 2.28-6.69).

Discussion: Being a fast decliner is linked to increased risk of future dementia.

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References

REFERENCES

    1. Elias MF, Beiser A, Wolf PA, Au R, White RF, D'Agostino RB. The preclinical phase of alzheimer disease: a 22‐year prospective study of the framingham cohort. Arch Neurol. 2000;57(6):808‐813. https://doi.org/10.1001/archneur.57.6.808
    1. Boraxbekk CJ, Lundquist A, Nordin A, Nyberg L, Nilsson LG, Adolfsson R. Free recall episodic memory performance predicts dementia ten years prior to clinical diagnosis: findings from the Betula longitudinal study. Dement Geriatr Cogn Disord Extra. May‐Aug 2015;5(2):191‐202. https://doi.org/10.1159/000381535
    1. Rajan KB, Wilson RS, Weuve J, Barnes LL, Evans DA. Cognitive impairment 18 years before clinical diagnosis of Alzheimer disease dementia. Neurology. Sep 2015;85(10):898‐904. https://doi.org/10.1212/wnl.0000000000001774
    1. Bäckman L, Jones S, Berger AK, Laukka EJ, Small B. Multiple cognitive deficits during the transition to Alzheimer's disease. J Intern Med. 2004;256(3):195‐204.
    1. Economou A, Papageorgiou SG, Karageorgiou C, Vassilopoulos D. Nonepisodic memory deficits in amnestic MCI. Cogn Behav Neurol. Jun 2007;20(2):99‐106. https://doi.org/10.1097/WNN.0b013e31804c6fe7

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