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Comment
. 2022 Aug;8(8):623-625.
doi: 10.1016/j.trecan.2022.06.003. Epub 2022 Jun 15.

Lymph node metastasis fuels systemic disease

Katherine S Ventre  1 , Triantafyllia Karakousi  1 , Amanda W Lund  2
Affiliations
Comment

Lymph node metastasis fuels systemic disease

Katherine S Ventre et al. Trends Cancer. 2022 Aug.

Abstract

The functional impact of lymph node (LN) metastasis on systemic tumor progression has been a controversial question for decades. In their recent paper published in Cell, Reticker-Flynn et al. demonstrate that sequential evasion of natural killer (NK) cell control and interferon (IFN)-dependent epigenetic adaptation enhances the probability of LN metastasis. Further, they show that, once formed, LN metastases expand systemic peripheral tolerance and promote distant organ metastasis.

Keywords: NK cells; interferons; lymph node metastasis; systemic tolerance.

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Conflict of interest statement

Declaration of interests The authors declare no conflicts of interest.

Comment on

  • Lymph node colonization induces tumor-immune tolerance to promote distant metastasis.
    Reticker-Flynn NE, Zhang W, Belk JA, Basto PA, Escalante NK, Pilarowski GOW, Bejnood A, Martins MM, Kenkel JA, Linde IL, Bagchi S, Yuan R, Chang S, Spitzer MH, Carmi Y, Cheng J, Tolentino LL, Choi O, Wu N, Kong CS, Gentles AJ, Sunwoo JB, Satpathy AT, Plevritis SK, Engleman EG. Reticker-Flynn NE, et al. Cell. 2022 May 26;185(11):1924-1942.e23. doi: 10.1016/j.cell.2022.04.019. Epub 2022 May 6. Cell. 2022. PMID: 35525247 Free PMC article.

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