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Editorial
. 2022 Jul;24(7):1249-1252.
doi: 10.1002/ejhf.2582. Epub 2022 Jul 5.

Moving beyond the vasodilator model in heart failure with reduced ejection fraction - lessons from sildenafil

Yogesh N V Reddy  1
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Free article
Editorial

Moving beyond the vasodilator model in heart failure with reduced ejection fraction - lessons from sildenafil

Yogesh N V Reddy. Eur J Heart Fail. 2022 Jul.
Free article
No abstract available

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References

    1. Borlaug BA, Reddy YNV. The role of the pericardium in heart failure: implications for pathophysiology and treatment. JACC Heart Fail. 2019;7:574-85.
    1. Desai AS, Solomon SD, Shah AM, Claggett BL, Fang JC, Izzo J, et al.; EVALUATE-HF Investigators. Effect of sacubitril-valsartan vs enalapril on aortic stiffness in patients with heart failure and reduced ejection fraction: a randomized clinical trial. JAMA. 2019;322:1077-84.
    1. Lewis GD, Lachmann J, Camuso J, Lepore JJ, Shin J, Martinovic ME, et al. Sildenafil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure. Circulation. 2007;115:59-66.
    1. Hirata K, Adji A, Vlachopoulos C, O'Rourke MF. Effect of sildenafil on cardiac performance in patients with heart failure. Am J Cardiol. 2005;96:1436-40.
    1. Guazzi M, Vicenzi M, Arena R. Phosphodiesterase 5 inhibition with sildenafil reverses exercise oscillatory breathing in chronic heart failure: a long-term cardiopulmonary exercise testing placebo-controlled study. Eur J Heart Fail. 2012;14:82-90.

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