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Review
. 2022 Jul;18(3):349-359.
doi: 10.1016/j.hfc.2022.02.010.

Therapy-Related Clonal Hematopoiesis: A New Link Between Cancer and Cardiovascular Disease

Yoshimitsu Yura  1 , Jesse D Cochran  2 , Kenneth Walsh  3
Affiliations
Review

Therapy-Related Clonal Hematopoiesis: A New Link Between Cancer and Cardiovascular Disease

Yoshimitsu Yura et al. Heart Fail Clin. 2022 Jul.

Abstract

Clonal hematopoiesis is a precancerous state that is recognized as a new causal risk factor for cardiovascular disease. Therapy-related clonal hematopoiesis is a condition that is often found in cancer survivors. These clonal expansions are caused by mutations in DNA damage-response pathway genes that allow hematopoietic stem cells to undergo positive selection in response to the genotoxic stress. These mutant cells increasingly give rise to progeny leukocytes that display enhanced proinflammatory properties. Recent experimental studies suggest that therapy-related clonal hematopoiesis may contribute to the medium- to long-term risk of genotoxic therapies on the cardiovascular system.

Keywords: Cardio-oncology; Clonal hematopoiesis; Inflammation.

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Figures

Figure 1.
Figure 1.
The cardiac toxicity associated with genotoxic therapies may stem from both direct and indirect mechanisms. Cancer patients treated with genotoxic therapies display a higher prevalence of clonal hematopoiesis, which may cause indirect cardiac toxicity. Created with BioRender.com.
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