Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2022 Aug;129(2):147-150.
doi: 10.1016/j.bja.2022.05.004. Epub 2022 Jun 17.

Breaking barriers in postoperative delirium

Niccolò Terrando  1 , Katerina Akassoglou  2
Affiliations
Free article
Editorial

Breaking barriers in postoperative delirium

Niccolò Terrando et al. Br J Anaesth. 2022 Aug.
Free article

Abstract

Systemic perturbations such as peripheral surgical trauma induce neurovascular, inflammatory, and cognitive changes. The blood-brain barrier is a key interface between the periphery and the central nervous system, and is critically involved in regulating neuroimmune interactions to maintain overall homeostasis. Mounting evidence suggests that blood-brain barrier dysfunction is a hallmark of ageing and multiple neurological conditions including Alzheimer's disease. We discuss a recent study published in the British Journal of Anaesthesia that describes blood-brain barrier changes and neuroinflammation in patients with postoperative delirium after non-intracranial surgery.

Keywords: biomarker; blood–brain barrier; cerebrospinal fluid; delirium; fibrinogen; neuroinflammation.

PubMed Disclaimer

Comment on