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. 2022 Jun 8:2022:6214785.
doi: 10.1155/2022/6214785. eCollection 2022.

The Determinants of Adolescent Glycolipid Metabolism Disorder: A Cohort Study

Xiao-Hua Liang  1 , Lun Xiao  2 , Jing-Yu Chen  3 , Ping Qu  1 , Xian Tang  1 , Yuwei Wang  4
Affiliations

The Determinants of Adolescent Glycolipid Metabolism Disorder: A Cohort Study

Xiao-Hua Liang et al. Int J Endocrinol. .

Abstract

Background: The increased prevalence of glycolipid metabolism disorders (GLMD) in childhood and adolescents has a well-established association with adult type 2 diabetes and cardiovascular diseases; therefore, determinants of GLMD need to be evaluated during this period.

Objectives: To explore the prevalence of and risk factors for GLMD from the prenatal period through childhood and adolescence.

Methods: A bidirectional cohort study which was established in 2014 and followed between March 1 and July 20, 2019, was used to illustrate the impact factors for GLMD. Stratified cluster sampling in urban-rural areas was used to include subjects from four communities in Chongqing. 2808 healthy children aged between 6 and 9 years in 2014 entered the cohort in 2014 and followed in 2019 with a follow-up rate of 70%. 2,136 samples (aged 11.68 ± 0.60 years) were included.

Results: The prevalence rates of insulin resistance (IR), prediabetes/diabetes, and dyslipidemia were 21.02%, 7.19%, and 21.61%, respectively. Subjects with an urban residence, no pubertal development, dyslipidemia in 2014, higher family income, and higher parental education had significantly elevated fasting insulin (FI) or homeostasis model assessment of insulin resistance (HOMA-IR) levels; subjects with female sex, no pubertal development, dyslipidemia in 2014, obesity, gestational hypertension, maternal weight gain above Institute of Medicine guidelines, and single parents had increased triglyceride or triglyceride/high-density lipoprotein (HDL). Adolescents with rural residence had higher HbA1c level.

Conclusion: We observed that the prevalence of GLMD was high in childhood and adolescents, and rural-urban areas, sex, pubertal development, dyslipidemia in a younger age, maternal obesity, and hypertension were associated with increased GLMD risk, suggesting that implementing the community-family intervention to improve the GLMD of children is essential.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

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Figure 1
Subjects inclusion process.
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References

    1. Koskinen J. S., Kyto V., Juonala M., et al. Childhood risk factors and carotid atherosclerotic plaque in adulthood: the cardiovascular risk in young finns study. Atherosclerosis . 2020;293:18–25. doi: 10.1016/j.atherosclerosis.2019.11.029. - DOI - PubMed
    1. Yin J., Li M., Xu L., et al. Insulin resistance determined by homeostasis model assessment (HOMA) and associations with metabolic syndrome among Chinese children and teenagers. Diabetology and Metabolic Syndrome . 2013;5(1):p. 71. doi: 10.1186/1758-5996-5-71. - DOI - PMC - PubMed
    1. Perak A. M., Ning H., Kit B. K., et al. Trends in levels of lipids and apolipoprotein B in US youths aged 6 to 19 years, 1999–2016. JAMA . 2019;321(19):1895–1905. doi: 10.1001/jama.2019.4984. - DOI - PMC - PubMed
    1. Iwani N. A. K. Z., Jalaludin M. Y., Zin R. M. W. M., et al. Triglyceride to HDL-C ratio is associated with insulin resistance in overweight and obese children. Scientific Reports . 2017;7(1) doi: 10.1038/srep40055.40055 - DOI - PMC - PubMed
    1. Hagman E., Reinehr T., Kowalski J., Ekbom A., Marcus C., Holl R. W. Impaired fasting glucose prevalence in two nationwide cohorts of obese children and adolescents. International Journal of Obesity . 2014;38(1):40–45. doi: 10.1038/ijo.2013.124. - DOI - PMC - PubMed

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