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Review
. 2022 May 31:11:2021-11-2.
doi: 10.7573/dic.2021-11-2. eCollection 2022.

Dermatology: how to manage facial hyperpigmentation in skin of colour

Affiliations
Review

Dermatology: how to manage facial hyperpigmentation in skin of colour

Siddiq Moolla et al. Drugs Context. .

Abstract

Hyperpigmentation disorders, such as post-inflammatory hyperpigmentation and melasma, are common conditions affecting all skin types. These conditions are largely benign and are influenced by numerous endogenous and exogenous factors impacting melanocyte activity and melanin production. Current treatment modalities for these conditions fall into broad categories, including photoprotection, topical and systemic therapies, chemical peels, and laser or light-based therapies. Biological differences in skin of colour require additional consideration when deciding on treatment and management. This narrative review provides an inclusive summary of these conditions and compares the current treatment options with a specific focus on skin of colour. Photoprotection and sunscreens protective against both UV and visible light are recommended for all individuals. Topical therapy is the recommended first-line treatment, with the gold standard being hydroquinone, which can be used alone or in combination with other agents. Chemical peels and laser or light-based therapies are also effective adjunctive methods of treatment; however, caution should be taken when used in patients with richly pigmented skin due to the increased risk of post-inflammatory hyperpigmentation.

Keywords: facial hyperpigmentation; melasma; post-inflammatory hyperpigmentation; skin of colour.

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Conflict of interest statement

Disclosure and potential conflicts of interest: The authors declare that they have no conflicts of interest relevant to this manuscript. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors is available for download at: https://www.drugsincontext.com/wp-content/uploads/2022/05/dic.2021-11-2-COI.pdf

References

    1. Alexis AF, Sergay AB, Taylor SC. Common dermatologic disorders in skin of color: a comparative practice survey. Cutis. 2007;80(5):387–394. - PubMed
    1. Sarma N, Chakraborty S, Poojary SA, et al. Evidence-based review, grade of recommendation, and suggested treatment recommendations for melasma. Indian Dermatol Online J. 2017;8(6):406. doi: 10.4103/IDOJ.IDOJ_187_17. - DOI - PMC - PubMed
    1. Taylor SC. Epidemiology of skin diseases in ethnic populations. Dermatologic Clinics. 2003;21(4):601–607. doi: 10.1016/S0733-8635(03)00075-5. - DOI - PubMed
    1. Kaufman BP, Aman T, Alexis AF. Postinflammatory hyperpigmentation: epidemiology, clinical presentation, pathogenesis and treatment. Am J Clin Dermatol. 2018;19(4):489–503. doi: 10.1007/S40257-017-0333-6. - DOI - PubMed
    1. Taraz M, Niknam S, Ehsani AH. Tranexamic acid in treatment of melasma: a comprehensive review of clinical studies. Dermatol Ther. 2017;30(3):e12465. doi: 10.1111/DTH.12465. - DOI - PubMed