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Review
. 2022 Jun 13:9:23333928221106269.
doi: 10.1177/23333928221106269. eCollection 2022 Jan-Dec.

Covid-19 Vaccine Acceptance and Determinant Factors among General Public in East Africa: A Systematic Review and Meta-Analysis

Astawus Alemayehu  1   2 , Abebaw Demissie  2   3 , Mohammed Yusuf  2   4 , Abebe Gemechu Lencha  5 , Lemessa Oljira  6
Affiliations
Review

Covid-19 Vaccine Acceptance and Determinant Factors among General Public in East Africa: A Systematic Review and Meta-Analysis

Astawus Alemayehu et al. Health Serv Res Manag Epidemiol. .

Abstract

Background: Vaccines are an effective and ideal solution that can reduce the burden of disease worldwide. Although vaccines are the most effective way to prevent infectious diseases. Anti-vaccine conspiracy theories impair vaccination acceptance intentions. Several studies were conducted in East Africa. However, these studies had reported inconsistent findings. Therefore, this systematic review aimed to pool the prevalence of COVID-19 vaccine acceptance and identify its determinants.

Methods: PubMed, Google Scholar, and GLOBAL HEALTH databases were used to retrieve previously published studies. All papers published in the English language up to February 28, 2022 were included. The result was written and reported according to the PRISMA updated guideline. A random-effect model was used to estimate the pooled prevalence and effect sizes. Heterogeneity was assessed using I2 test statistics. Publication bias was assessed using funnel plot and egger's test statistics. Statistical tests result at P-value<0.05 were declared as having significance.Result: A total of 25 Cross-sectional studies with a total sample size of 33,044 were included in this study. The pooled prevalence of Covid-19 vaccine acceptance was 60.2%, (95%CI: 52.8- 67.3). Egger's test statistics (P = 0.003) showed there is a significant publication bias. Attending above secondary school (AOR: 2.1, 95%CI: 1.37, 2.96), having good knowledge about the vaccine (AOR: 2.1, 95%CI: 1.6, 2.8), having a positive attitude towards vaccine (AOR: 3.8, 95%CI: 2.3, 6.2), history of COVID-19 infection (AOR: 2.7, 95%CI: 1.6, 4.7) and being male (AOR: 1.8, 95%CI: 1.2, 2.7) were found to have a significant association with COVID-19 vaccine acceptance.

Conclusion: The COVID-19 vaccination acceptance rate was good, but it could be improved. The findings could help governments to figure out the best way to carry out COVID-19 mass vaccination campaigns. There is a lack of data in most countries. Therefore, we suggest more studies be conducted in the future.

Keywords: COVID-19 vaccine; vaccine acceptance; vaccine acceptance determinants.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Prisma flow chart shows study selection for systematic review and meta-analysis of COVID-19 Vaccine acceptance and determinants among general population in East Africa, 2022.
Figure 2.
Figure 2.
Forest plot of pooled prevalence of COVID-19 vaccine acceptance among general population in East Africa, 2022.
Figure 3.
Figure 3.
Forest plot shows subgroup analysis of pooled prevalence of COVID-19 vaccine acceptance among general population in East Africa by country, 2022.
Figure 4.
Figure 4.
Forest plot shows subgroup analysis of pooled prevalence of COVID-19 vaccine acceptance among general population in East Africa by study participants, 2022.
Figure 5.
Figure 5.
Bubble plot show the association of a sample size of the study and COVID-19 vaccine acceptance based on meta-regression.
Figure 6.
Figure 6.
Funnel plot shows publication bias with imputation of missing studies of pooled prevalence of COVID-19 vaccine acceptance among general population in east Africa, 2022.
Figure 7.
Figure 7.
The sensitivity analysis result of 25 included studies conducted on COVID-19 vaccine acceptance among general population in East Africa, 2022.
See this image and copyright information in PMC

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