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Review
. 2022 Jun 1:13:901365.
doi: 10.3389/fimmu.2022.901365. eCollection 2022.

Novel Immune-Based treatments for Diffuse Large B-Cell Lymphoma: The Post-CAR T Cell Era

Suheil Albert Atallah-Yunes  1 , Michael J Robertson  1 , Utpal P Davé  1   2 , Paola Ghione  3 , Fabiana Perna  1
Affiliations
Review

Novel Immune-Based treatments for Diffuse Large B-Cell Lymphoma: The Post-CAR T Cell Era

Suheil Albert Atallah-Yunes et al. Front Immunol. .

Abstract

Prognosis for patients with refractory/relapsed (R/R) diffuse large B-cell lymphoma (DLBCL) is poor. Immune-based therapeutic treatments such as CD19 Chimeric Antigen Receptor (CAR) T cell therapies have dramatically changed the treatment landscape for R/R DLBCL leading to durable remissions in ~ 50% of patients. However, there remains an unmet need for developing novel therapies to improve clinical outcomes of patients not responding or relapsing after CAR T cell therapies. Lack of suitable immunotherapeutic targets and disease heterogeneity represent the foremost challenges in this emerging field. In this review, we discuss the recently approved and emerging novel immunotherapies for patients with R/R DLBCL in the post-CAR T era and the cell surface targets currently used.

Keywords: chimeric antigen receptor T-cell therapy; diffuse large B-cell lymphoma; discovery; high-risk; immunotherapy; target.

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Conflict of interest statement

PG participated in advisory boards for Astra Zeneca, Daiichi Sanyo, Secura Bio and Kyowa Hakko Kirin. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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