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Review
. 2022 Jun 3:13:913215.
doi: 10.3389/fimmu.2022.913215. eCollection 2022.

From CD16a Biology to Antibody-Dependent Cell-Mediated Cytotoxicity Improvement

Loïs Coënon  1   2 , Martin Villalba  2   3
Affiliations
Review

From CD16a Biology to Antibody-Dependent Cell-Mediated Cytotoxicity Improvement

Loïs Coënon et al. Front Immunol. .

Abstract

Antibody-dependent cell-mediated cytotoxicity (ADCC) is a potent cytotoxic mechanism that is mainly mediated in humans by natural killer (NK) cells. ADCC mediates the clinical benefit of several widely used cytolytic monoclonal antibodies (mAbs), and increasing its efficacy would improve cancer immunotherapy. CD16a is a receptor for the Fc portion of IgGs and is responsible to trigger NK cell-mediated ADCC. The knowledge of the mechanism of action of CD16a gave rise to several strategies to improve ADCC, by working on either the mAbs or the NK cell. In this review, we give an overview of CD16a biology and describe the latest strategies employed to improve antibody-dependent NK cell cytotoxicity.

Keywords: ADCC; CD16a; NK cells; cell therapy; monoclonal antibodies.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Different strategies to improve ADCC. NK cell-mediated ADCC can be enhanced by expanding them with specific protocols or by stimulating them with certain cytokine cocktails. It could be possible to select more potent NK cell subsets based on their phenotype or genotype. Engineering mAbs are also an efficient way to increase ADCC activity. Lastly, tumor cells can be sensitized to NK cell activity by modifying their metabolism. ADCC, antibody-dependent cell-mediated cytotoxicity; Ag, antigen; CIML NK, memory-like natural killer cells; mAbs, monoclonal antibodies.
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