Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jun 3:16:905121.
doi: 10.3389/fnins.2022.905121. eCollection 2022.

Altered Default Mode Network Functional Connectivity in Parkinson's Disease: A Resting-State Functional Magnetic Resonance Imaging Study

Lu Chen  1 , Ting Huang  2 , Di Ma  3 , Yu-Chen Chen  4
Affiliations

Altered Default Mode Network Functional Connectivity in Parkinson's Disease: A Resting-State Functional Magnetic Resonance Imaging Study

Lu Chen et al. Front Neurosci. .

Abstract

Purpose: Whether the intrinsic functional connectivity pattern of the default mode network (DMN) is involved in the progression of cognitive decline in Parkinson's disease (PD) remains unclear. This study aimed to investigate the intrinsic functional connectivity (FC) pattern of the DMN anchored on the posterior cingulate cortex (PCC) in patients with PD by resting-state functional magnetic resonance imaging (fMRI).

Methods: Fifty patients with PD and 50 healthy controls (HCs) were included for resting-state fMRI scanning. A seed-based FC method was used to reveal FC patterns in the DMN with region of interest (ROI) in the PCC. Relationships between FC patterns and disease severity (UPDRS-III) were detected.

Results: Compared with the HCs, the patients with PD showed increased FC between the PCC and the right precuneus, left cuneus, and right angular gyrus. In the PD group, the increased FC values in the right precuneus were significantly and positively correlated with motor severity as assessed with UPDRS-III scores (rho = 0.337, p = 0.02).

Conclusion: Our result highlights that the patients with PD showed increased FC between the PCC and the right precuneus, left cuneus, and right angular gyrus in the DMN. The altered connectivity pattern in the DMN may play a crucial role in the neurophysiological mechanism of cognitive decline in patients with PD. These findings might provide new insights into neural mechanisms of cognitive decline in PD.

Keywords: Parkinson’s disease; cognitive decline; default mode network; functional connectivity; functional magnetic resonance imaging.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer ZX declared a past co-authorship with the author Y-CC to the handling editor.

Figures

FIGURE 1
FIGURE 1
Results of the two components representing the default mode network (DMN) by one-sample t-test in patients with Parkinson’s disease (PD) and healthy controls.
FIGURE 2
FIGURE 2
Compared with the healthy controls, the patients with PD exhibited enhanced FC between the PCC and the right precuneus (R-PreCUN), left cuneus (L-CUN), and right angular gyrus (R-ANG) (two-tailed, voxel-level: p < 0.01, GRF correction, cluster-level: p < 0.05).
FIGURE 3
FIGURE 3
(A) Positive correlations between enhanced functional connectivity (FC) between the PCC and the right PreCUN and UPDRS-III scores in patients with PD (rho = 0.337, p = 0.02). (B) Moreover, the enhanced FC values in the right ANG were positively associated with the Unified Parkinson’s Disease Rating Scale part III (UPDRS-III) scores (rho = 0.527, p < 0.001).
See this image and copyright information in PMC

References

    1. Bloem B. R., Okun M. S., Klein C. (2021). Parkinson’s disease. Lancet 397 2284–2303. - PubMed
    1. Boylan C., Trueswell J. C., Thompson-Schill S. L. (2015). Compositionality and the angular gyrus: a multi-voxel similarity analysis of the semantic composition of nouns and verbs. Neuropsychologia 78 130–141. 10.1016/j.neuropsychologia.2015.10.007 - DOI - PMC - PubMed
    1. Buckner R. L., Andrews-Hanna J. R., Schacter D. L. (2008). The brain’s default network: anatomy, function, and relevance to disease. Ann. N. Y. Acad. Sci. 1124 1–38. 10.1196/annals.1440.011 - DOI - PubMed
    1. Chen L. A. T. V., Xu J., Moeller S., Ugurbil K., Yacoub E., Feinberg D. A. (2015). Evaluation of highly accelerated simultaneous multi-slice EPI for fMRI. Neuroimage 104 452–459. 10.1016/j.neuroimage.2014.10.027 - DOI - PMC - PubMed
    1. Churchill N. W., Hutchison M. G., Graham S. J., Schweizer T. A. (2021). Long-term changes in the small-world organization of brain networks after concussion. Sci. Rep. 11:6862. 10.1038/s41598-021-85811-4 - DOI - PMC - PubMed

LinkOut - more resources