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Case Reports
. 2022 Jun 10;14(6):e25810.
doi: 10.7759/cureus.25810. eCollection 2022 Jun.

A Rare Case of Guillain-Barré Syndrome Associated With SARS-CoV-2 Infection Requiring Mechanical Ventilation

Rahul Prakash Rane  1 , Ashish Jain  1 , Khandakar M Hussain  1 , Sarvesh Naik  1 , Asna Shahab  1
Affiliations
Case Reports

A Rare Case of Guillain-Barré Syndrome Associated With SARS-CoV-2 Infection Requiring Mechanical Ventilation

Rahul Prakash Rane et al. Cureus. .

Abstract

Coronavirus disease 2019 (COVID-19) has become a worldwide pandemic since the first case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was identified in December 2019. Numerous neurological consequences have been reported with COVID-19 infection and its approved vaccines. However, Guillain-Barré syndrome (GBS) is a rare neurological complication associated with COVID-19 infection. This case report describes a 62-year-old female with a three-week history of COVID-19 infection who presented with symmetric polyneuropathy in bilateral lower extremities that progressed to involve bilateral upper extremities and skeletal muscles of respiration, resulting in respiratory distress and necessitating intubation and mechanical ventilation. Cerebrospinal fluid (CSF) analysis revealed albumino-cytologic dissociation, and our patient met the National Institute of Neurological Disorders and Strokes (NINDS) criteria for diagnosing Guillain-Barré Syndrome, making GBS to be the most likely diagnosis. This case report aims to strengthen the association of GBS with COVID-19 infection and describes the hospital course of GBS.

Keywords: covid-19; guillain-barre syndrome (gbs); invasive mechanical ventilation; neuromuscular diseases; post covid gbs/ atm; sars-cov-2.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. MRI of the head in transverse plane showing periventricular hyper-intensities.
See this image and copyright information in PMC

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