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Review
. 2022 May 26:14:885226.
doi: 10.3389/fnagi.2022.885226. eCollection 2022.

Long Term Cognitive Function After Cardiac Arrest: A Mini-Review

Guri Hagberg  1   2 , Håkon Ihle-Hansen  1   3 , Else Charlotte Sandset  2 , Dag Jacobsen  4 , Henning Wimmer  4 , Hege Ihle-Hansen  1   2
Affiliations
Review

Long Term Cognitive Function After Cardiac Arrest: A Mini-Review

Guri Hagberg et al. Front Aging Neurosci. .

Abstract

Out-of-hospital cardiac arrest (OHCA) is a leading cause of mortality worldwide. With better pre- and inhospital treatment, including cardiopulmonary resuscitation (CPR) as an integrated part of public education and more public-access defibrillators available, OHCA survival has increased over the last decade. There are concerns, after successful resuscitation, of cerebral hypoxia and degrees of potential acquired brain injury with resulting poor cognitive functioning. Cognitive function is not routinely assessed in OHCA survivors, and there is a lack of consensus on screening methods for cognitive changes. This narrative mini-review, explores available evidence on hypoxic brain injury and long-term cognitive function in cardiac arrest survivors and highlights remaining knowledge deficits.

Keywords: cardiac arrest; cognition; cognitive impaiment; dementia; hypoxic brain injury.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Areas susceptible for global anoxic-ischemic brain injury and related cognitive symptoms. Illustration adapted from servier medial art.
See this image and copyright information in PMC

References

    1. Barber R., Gholkar A., Scheltens P., Ballard C., McKeith I. G., O’Brien J. T. (1999). Medial temporal lobe atrophy on MRI in dementia with Lewy bodies. Neurology 52 1153–1158. - PubMed
    1. Becker L. B., Aufderheide T. P., Geocadin R. G., Callaway C. W., Lazar R. M., Donnino M. W., et al. (2011). Primary outcomes for resuscitation science studies: a consensus statement from the American Heart Association. Circulation 124 2158–2177. 10.1161/CIR.0b013e3182340239 - DOI - PMC - PubMed
    1. Benjamin E. J., Virani S. S., Callaway C. W., Chamberlain A. M., Chang A. R., Cheng S., et al. (2018). Heart Disease and Stroke Statistics-2018 Update: a Report From the American Heart Association. Circulation 137 e67–e492. - PubMed
    1. Bettcher B. M., Libon D. J., Kaplan E., Swenson R., Penney D. L. (2011). “Digit Symbol Substitution Test,” in Encyclopedia of Clinical Neuropsychology, eds Kreutzer J. S., DeLuca J., Caplan B. (New York, NY: Springer; ), 849–853.
    1. Buanes E. A., Gramstad A., Søvig K. K., Hufthammer K. O., Flaatten H., Husby T., et al. (2015). Cognitive function and health-related quality of life four years after cardiac arrest. Resuscitation 89 13–18. 10.1016/j.resuscitation.2014.12.021 - DOI - PubMed

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