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Review
. 2022 May 26:13:843867.
doi: 10.3389/fendo.2022.843867. eCollection 2022.

PCOS and Role of Cumulus Gene Expression in Assessing Oocytes Quality

Nurainie Sayutti  1 , Muhammad Azrai Abu  1   2 , Mohd Faizal Ahmad  1   2
Affiliations
Review

PCOS and Role of Cumulus Gene Expression in Assessing Oocytes Quality

Nurainie Sayutti et al. Front Endocrinol (Lausanne). .

Abstract

The global infertility rate has been declining from year to year. PCOS is one of the treatable accountable causes contributing to anovulatory infertility. Nevertheless, the success rate of treatments and live-birth outcomes especially involving assisted reproductive techniques is still not very promising. There is a reduction in the development potential of oocytes and high-quality embryos in PCOS patients compared to non-PCOS patients. A critical step in IVF treatment is the assessment of oocyte and embryo competence before embryo transfer. Oocytes in metaphase II are very fragile. Repeated morphological assessment on these oocytes may directly impair the quality and affect the whole process. Identification of potential biomarkers especially in the cumulus cells oocytes complex will help to predict the outcome and may create space for improvement. This review has explored gene expression in cumulus cells with regards to oocytes quality in both normal and PCOS women. The gene expression was classified according to their physiological function such as the contribution on cumulus expansion, cumulus cells apoptosis, and glucose metabolism. Collectively, the review suggested that positive expression of HAS2, PTX3, GREM1, and VCAN may correlate with good quality oocytes and can be used as an indicator among PCOS women.

Keywords: assisted reproductive technique; cumulus cells gene expression; infertility; oocyte quality; polycystic ovarian syndrome; review.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Stages of folliculogenesis. The ovarian follicle will go through primordial, primary, secondary, antral, and pre-ovulatory or late antral developmental stages. Finally, an oocyte is released during ovulation, leaving the remaining ruptured follicle, known as the corpus luteum.
Figure 2
Figure 2
Close-up diagram of the cumulus-oocyte complex.
Figure 3
Figure 3
Summary of selected potential genes related to embryo viability in human cumulus cells.
Figure 4
Figure 4
Multiple glucose metabolism pathways within the cumulus-oocyte complex (COC).
See this image and copyright information in PMC

References

    1. Lizneva D, Suturina L, Walker W, BRakta S, Gavrilova-Jordan L, Azzizz R. Criteria, Prevalence, and Phenotypes of Polycytsic Ovary Syndrome. Fertil Steril (2016) 106:6–15. - PubMed
    1. Da Broi MG, Giorgi VSI, Wang F, Keefe DL, Albertini D, Navarro PA. Influence of Follicular Fluid and Cumulus Cells on Oocyte Quality: Clinical Implications. J Assisted Reprod Genet (2018) 35:735–51. doi: 10.1007/s10815-018-1143-3 - DOI - PMC - PubMed
    1. Robert C, Gilbert I. Female Reproduction. In: Encyclopedia of Reproduction, 2nd ed. (2018) 6. Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, USA: Academic Press; Editor: Skinner MK.
    1. Guzeloglu-Kayisli O, Lalioti MD, Aydiner F, Sasson I, Ilbay O, Sakkas D, et al. . Embryonic Poly(A)-Binding Protei (EPAB) Is Required for Oocyte Maturation and Female Fertility in Mice. Biochem J (2012) 446:47–58. - PMC - PubMed
    1. Catteau-Jonard S, Dewaily D. Pathophysiology of Disturbed Folliculogenesis in PCOS. Médecine la Reprod (2009) 11(3):191–7. doi: 10.1684/mte.2009.0241 - DOI