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. 2022 Jun 10:2022:9578307.
doi: 10.1155/2022/9578307. eCollection 2022.

The Effect and Related Mechanism of Action of Astragalus Compatible with Curcumin against Colon Cancer Metastasis in Mice

Jiafei Wu  1 , Decai Tang  1
Affiliations

The Effect and Related Mechanism of Action of Astragalus Compatible with Curcumin against Colon Cancer Metastasis in Mice

Jiafei Wu et al. Gastroenterol Res Pract. .

Retraction in

Abstract

Colon cancer (CC) is the third most common tumor worldwide. Colon carcinogenesis is strongly linked to inflammation. The initiation and progression of colon cancer may be influenced by epigenetic processes. Cancer metastasis is a multistep process involving several genes and their products. During tumor metastasis, cancer cells first enhance their proliferative capacity by lowering autophagy and apoptosis, and then, their capacity is stimulated by boosting tumors' ability to take nutrients from the outside via angiogenesis. Traditional treatment focuses on eliminating tumor cells by triggering cell death or activating the immune system, which often results in side effects or chemoresistance recurrence. On the contrary, Chinese medicine theory considers the patient's entire inner system and aids in tumor shrinkage while also taking into account the mouse' general health. Because many Chinese herbal medicines (CHM) are consumed as food, using edible CHMs as a diet resource therapy for colon cancer treatment is a viable option. Two traditional Chinese herbs, Astragalus membranaceus and Curcuma zedoaria, are commonly utilized jointly in colon cancer preventive therapy. As a result, the anticancer effect of astragalus and curcumin (AC) on colon cancer suppression in an 18-week AOM-DSS colon cancer mouse model is investigated in this research. These findings may offer a scientific foundation for investigating colon cancer diagnostic biomarkers and therapeutic application of AC in colon cancer treatment. These studies also highlighted the potential effect and mechanism of AC in the treatment of colon cancer, as well as providing insight into how to effectively use it.

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Conflict of interest statement

There are no competing interests declared by the researchers.

Figures

Figure 1
Figure 1
Flow of the methodology used.
Figure 2
Figure 2
Anticancer activity of medicinal plant extracts.
Figure 3
Figure 3
Cell viability vs. milligram per millilitre HQEZ-induced HCT116.
Figure 4
Figure 4
Cell viability vs. milligrams per millilitre.
Figure 5
Figure 5
HQEZ reduced migration, despite the low dose that did not cause apoptosis.
Figure 6
Figure 6
Invasion of HCT116 cells, p < 0.05 compared with vehicle.
Figure 7
Figure 7
p < 0.05 when compared to vehicle exhibits HCT116 cell invasion.
Figure 8
Figure 8
(a, b) Effect of HQEZ on β-catenin.
Figure 9
Figure 9
WAY-262611, a possible promoter of -catenin, saved HCT116 cells against HQEZ.
Figure 10
Figure 10
Stabilization of β-catenin was essential to retain the potential to metastasize.
Figure 11
Figure 11
Curcuma or mixed solution but not the Astragalus reduced the invasion of HCT116.
See this image and copyright information in PMC

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References

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