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Review
. 2022 Jun 3:10:869628.
doi: 10.3389/fped.2022.869628. eCollection 2022.

The Perspectives of Biomarkers in Predicting the Survival of the Renal Graft

Paul Luchian Aldea  1 , Andreea Liana Rachisan  2 , Bogdan Ioan Stanciu  3 , Andrei Picos  4 , Alina Monica Picos  5 , Dan Ioan Delean  2 , Ramona Stroescu  6 , Magdalena Iuliana Starcea  7 , Cristina Maria Borzan  1 , Florin Ioan Elec  8
Affiliations
Review

The Perspectives of Biomarkers in Predicting the Survival of the Renal Graft

Paul Luchian Aldea et al. Front Pediatr. .

Abstract

Kidney transplantation (KT) is currently the elective approach for patients with end-stage renal disease. Although it is a safe choice for these patients, the early complications can lead to graft dysfunction. One of the most redoubtable complications is delayed graft function (DGF), having no specific treatment. The effects of DGF on the graft survival are large enough to justify the formulation of specific biological protocols. Therefore, discovering biomarkers of acute impairment in renal transplanted patients is required. Creatinine is a poor marker to establish the kidney injury. Estimated glomerular filtration rate together with creatinine is ready to approximately measure the kidney function. Different serum and urine proteins are being studied as possible predictive biomarkers for delayed graft function. This review will concentrate on recent and existing research which provide insight concerning the contribution of some molecules for the estimation and evaluation of graft function after kidney transplantation. Further studies examining various aspects of DGF after KT are urgently needed to address a hitherto less-known clinical question.

Keywords: beta 2 microglobulin; biomarkers; cystatin C; graft function; kidney injury molecule 1; neutrophil gelatinase-related lipoprotein.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Traditional and new biomarkers that can indicate kidney damage.
See this image and copyright information in PMC

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