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Review
. 2022 Jul;247(13):1135-1147.
doi: 10.1177/15353702221102895. Epub 2022 Jun 20.

Revolutionized virome research using systems microbiology approaches

Suwalak Chitcharoen  1   2 , Pavaret Sivapornnukul  2   3 , Sunchai Payungporn  2   3
Affiliations
Review

Revolutionized virome research using systems microbiology approaches

Suwalak Chitcharoen et al. Exp Biol Med (Maywood). 2022 Jul.

Abstract

Currently, both pathogenic and commensal viruses are continuously being discovered and acknowledged as ubiquitous components of microbial communities. The advancements of systems microbiological approaches have changed the face of virome research. Here, we focus on viral metagenomic approach to study virus community and their interactions with other microbial members as well as their hosts. This review also summarizes challenges, limitations, and benefits of the current virome approaches. Potentially, the studies of virome can be further applied in various biological and clinical fields.

Keywords: Virome; systems microbiology; viral metagenomic; virus discovery; virus–host interaction.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Overview of trans-kingdom interaction among viromes and hosts community. Figure created using BioRender (https://biorender.com/). (A color version of this figure is available in the online journal.)
Figure 2.
Figure 2.
The workflow of virome research based on metagenomic technique. Figure created using BioRender (https://biorender.com/). (A color version of this figure is available in the online journal.)
See this image and copyright information in PMC

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