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. 2022 Mar 17;44(3):1326-1331.
doi: 10.3390/cimb44030089.

hERG1 Potassium Channel Expression in Colorectal Adenomas: Comparison with Other Preneoplastic Lesions of the Gastrointestinal Tract

Elena Lastraioli  1 , Jessica Iorio  1 , Federica Petrelli  2 , Anna Tomezzoli  3 , Serena Battista  4 , Maria Raffaella Ambrosio  2 , Mariella Chiudinelli  5 , Federica De Salvatore  6 , Luca Messerini  1 , Vincenzo Villanacci  6 , Luca Saragoni  7 , Annarosa Arcangeli  1 ; Gruppo Italiano di Ricerca Cancro Gastrico (GIRCG)
Affiliations

hERG1 Potassium Channel Expression in Colorectal Adenomas: Comparison with Other Preneoplastic Lesions of the Gastrointestinal Tract

Elena Lastraioli et al. Curr Issues Mol Biol. .

Abstract

Preneoplastic lesions represent a useful target for early diagnosis and follow-up of gastrointestinal malignancies. hERG1 channel expression was tested by immunohistochemistry (IHC) in a cohort of colorectal adenoma samples belonging to Italian subjects. Overall, hERG1 was expressed in 56.5% of cases with both high staining intensity and a high percentage of positive cells. Moreover, hERG1 was expressed in a higher percentage of dysplastic adenomas with respect to hyperplastic lesions, and the proportion of positive samples further increased in patients with high-grade dysplasia. Comparing hERG1 expression in other preneoplastic lesions of the GI tract (gastric dysplasia and Barrett's esophagus), it emerged that in all the conditions, hERG1 was expressed with a diffused pattern, throughout the cell, with variable staining intensity within the samples. The highest expression was detected in gastric dysplasia samples and the lowest in Barrett's esophagus at similar levels observed in colorectal adenomas. Our results show that hERG1 is aberrantly expressed in human preneoplastic lesions of the gastrointestinal tract and has a different pattern of expression and role in the different sites. Overall, the detection of hERG1 expression in preneoplastic lesions could represent a novel diagnostic or prognostic marker of progression in the gastrointestinal tract.

Keywords: Barrett’ s esophagus; colorectal adenomas; gastric dysplasias; hERG1 potassium channels.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
hERG1 potassium channel expression in CRA. (A,B) representative samples showing a high hERG1 expression in the epithelial cells as well as in plasma cells (see arrows in panel (B) and inset to panel (B). Scale bar: 100 μm. (C) Histogram showing hERG1 expression according to the presence of dysplasia. White bars: hERG1 negative, Blue bars: hERG1 positive. (D) Histogram showing hERG1 expression according to the grade of dysplasia. White bars: hERG1 negative, Blue bars: hERG1 positive. Representative slides of the two groups are also shown.
Figure 2
Figure 2
hERG1 potassium channel expression in preneoplastic lesions of the GI tract. (A,B) Gastric dysplasia. (C,D) Barrett’s esophagus. (E,F) colorectal adenoma. Scale bar:100 μm. (G) Histogram showing hERG1 expression in the three groups.
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