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. 2022 Apr 13;44(4):1713-1724.
doi: 10.3390/cimb44040118.

Associations of APOE Gene Variants rs429358 and rs7412 with Parameters of the Blood Lipid Profile and the Risk of Myocardial Infarction and Death in a White Population of Western Siberia

Sergey Semaev  1   2 , Elena Shakhtshneider  1   2 , Liliya Shcherbakova  2 , Dinara Ivanoshchuk  1   2 , Pavel Orlov  1   2 , Sophia Malyutina  2 , Valery Gafarov  2 , Yuliya Ragino  2 , Mikhail Voevoda  1
Affiliations

Associations of APOE Gene Variants rs429358 and rs7412 with Parameters of the Blood Lipid Profile and the Risk of Myocardial Infarction and Death in a White Population of Western Siberia

Sergey Semaev et al. Curr Issues Mol Biol. .

Abstract

The present study aimed to analyze possible associations of rs7412 and rs429358 of the APOE gene with lipid profile parameters, the risk of myocardial infarction, and death in the mostly white population of Western Siberia (Russia). The study population was selected from a sample surveyed within the framework of the Health, Alcohol and Psychosocial Factors In Eastern Europe (HAPIEE) study (9360 subjects, age 53.8 ± 7.0 years, males/females 50/50). PCR was conducted with fluorescence detection according to the TaqMan principle on a real-time PCR machine. The frequency of a minor allele (C) of rs429358 was 0.13, and the frequency of a minor allele (T) of rs7412 was 0.09. In our study, the woman with the rare ɛ1/ɛ4 genotype had substantial aberrations in blood lipid levels. In Kaplan-Meier curves, statistically significant differences were revealed in the prognosis of survival within the subgroup of females who had a myocardial infarction (p = 0.0006): the prognosis was worse for carriers of the ɛ2/ɛ2 genotype and for ɛ4/ɛ4 carriers. Survival analysis regarding deaths from all causes showed (p = 0.0238) that female carriers of the ɛ2/ɛ4 genotype had a worse prognosis than did carriers of other genotypes. Thus, in the population of Western Siberia (Russia), we confirmed statistically significant associations between rs7412 & rs429358 genotypes and lipid profile parameters.

Keywords: Western Siberia; lipid profile; risk of death; risk of myocardial infarction; rs429358; rs7412; white population.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The survival plot for myocardial infarction in the female subgroup: the prognosis was worse for carriers of the ɛ2/ɛ2 genotype (green curve) and for ɛ4/ɛ4 carriers (red curve) (p = 0.0006). time_death_2015: this is the time (in years) from the start of the observation (December 2002) to the end of the study (the occurrence of the outcome or the end of the observation period: December 2015). Cum Survival: the probability that the case has no outcome until the time point that we choose along the horizontal axis.
Figure 2
Figure 2
The survival plot for myocardial infarction in the female subgroup. The prognosis was worse for ɛ2/ɛ2 carriers (blue curve) versus the widespread ɛ3/ɛ3 genotype (green curve) (p < 0.0001). time_im2015: this is the time (in years) from the start of the observation (December 2002) to the end of the study (the occurrence of myocardial infarction or the end of the observation period: December 2015). Cum Survival: the probability that the case has no outcome until the time point that we choose along the horizontal axis.
See this image and copyright information in PMC

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