Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978;13(3):190-6.
doi: 10.1007/BF02773663.

Effect of intravenous infusion of somatostatin on gastric, pancreatic and biliary secretion in the rat

M Moriga, K Kojima, M Aono, H Uchino, H Yajima

Effect of intravenous infusion of somatostatin on gastric, pancreatic and biliary secretion in the rat

M Moriga et al. Gastroenterol Jpn. 1978.

Abstract

The effect of somatostatin (GH-RIH) on gastric, pancreatic and biliary secretion was examined in the anesthetized rats. Intravenous infusion of the hormone, in graded doses ranging from 1 to 16 microgram/kg/hr, produced a dose dependent inhibition of pentagastrin, 1.5 microgram/kg/hr, induced acid secretion, reaching about 54% of control level at the dose of 16 microgram/kg/hr. Somatostatin, 4, 16 and 64 microgram/kg/hr, inhibited the pancreatic juice volume stimulated by intravenous injection of secretin, 1 u/kg, as a bolus. Somatostastin, 2, 8, 32 and 128 microgram/kg/30 min, did not change the bile flow rate in control period. Somatostatin may play a physiological role in the regulation of the secretory process of the stomach and pancreas.

PubMed Disclaimer

References

    1. Agents Actions. 1975 Oct;5(4):306-10 - PubMed
    1. Lancet. 1973 Dec 8;2(7841):1299-301 - PubMed
    1. Acta Hepatogastroenterol (Stuttg). 1977 Aug;24(4):529-65 - PubMed
    1. Lancet. 1975 Apr 19;1(7912):886-7 - PubMed
    1. J Gen Physiol. 1932 Sep 20;16(1):59-63 - PubMed