Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Sep;85(3):e56-e58.
doi: 10.1016/j.jinf.2022.05.043. Epub 2022 Jun 18.

Reactivation/relapse of SARS-CoV-2 in a child following haematopoietic stem cell transplantation, confirmed by whole genome sequencing, following apparent viral clearance

J Hatcher  1 , E Gil  2 , N Storey  2 , J R Brown  2 , J C Hartley  2 , J Breuer  2 , G Lucchini  3 , K Rao  3 , D O'Connor  4 , H Dunn  2
Affiliations
Comment

Reactivation/relapse of SARS-CoV-2 in a child following haematopoietic stem cell transplantation, confirmed by whole genome sequencing, following apparent viral clearance

J Hatcher et al. J Infect. 2022 Sep.
No abstract available

Keywords: Paediatric; Reactivation; SARS-CoV-2; Transplantation.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest None declared.

Figures

Fig. 1
Fig. 1
Timeline comparing RT-PCR positivity in different sample types, sequencing, neutropenic episodes, and location.
Fig. 2
Fig. 2.
SNIPIT plot demonstrating the 5 nucleotide differences between the June 2021 sequence and the December 2021, comprising of 4 single nucleotide variants and 1 ambiguous base call. Variants were called against the Wuhan-Hu-1 reference sequence (NC_045512.2).
See this image and copyright information in PMC

Comment on

References

    1. Chappell H, Patel R, Driessens C, Tarr A W, Irving W L, Tighe P J, et al. Immunocompromised children and young people are at no increased risk of severe COVID-19. J Infect. 2022;84(1):31–39. - PMC - PubMed
    1. Yahav D, Yelin D, Eckerle I, Eberhardt C S, Wang J, Cao B. Definitions for coronavirus disease 2019 reinfection, relapse and PCR re-positivity. Clin Microbiol Infect. 2021;27(3):315–318. - PMC - PubMed
    1. Stirrup O, Hughes J, Parker M, Partridge D G, Shepherd J G, Blackstone J, et al. Rapid feedback on hospital onset SARS-CoV-2 infections combining epidemiological and sequencing data. Elife. 2021;10:e65828. - PMC - PubMed
    1. Singanayagam A, Patel M, Charlett A, Bernal J L, Saliba V, Ellis J, et al. Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020. Euro Surveill. 2020;25(32) - PMC - PubMed
    1. Brown JR, O'Sullivan DM, Shah D, Atkinson L, Pereira R P A, Whale A S, et al. Comparison of SARS-CoV-2N gene real-time RT-PCR targets and commercially available mastermixes. J Virol Methods. 2021;295 - PMC - PubMed