doi: 10.1016/j.injury.2022.05.009.
Epub 2022 May 26.
Health care utilization and outcomes in older adults after Traumatic Brain Injury: A CENTER-TBI study
Marjolein van der Vlegel
1
, Ana Mikolić
2
, Quentin Lee Hee
2
, Z L Rana Kaplan
2
, Isabel R A Retel Helmrich
2
, Ernest van Veen
3
, Nada Andelic
4
, Nicole V Steinbuechel
5
, Anne Marie Plass
5
, Marina Zeldovich
5
, Lindsay Wilson
6
, Andrew I R Maas
7
, Juanita A Haagsma
2
, Suzanne Polinder
2
; CENTER-TBI Participants and Investigators
Collaborators,
Affiliations
Collaborators
-
CENTER-TBI Participants and Investigators:
Cecilia A Kerlund 8 , Pradeep George 8 , Linda Lanyon 8 , Visakh Muraleedharan 8 , David Nelson 8 , Krisztina Amrein 9 , Erzsébet Ezer 9 , Noémi Kovács 9 , Béla Melegh 9 , József Nyirádi 9 , Viktória Tamás 9 , Zoltán Vámos 9 , Abayomi Sorinola 9 , Nada Andelic, Lasse Andreassen 10 , Audny Anke 10 , Shirin Frisvold 10 , Anna Antoni 11 , Elisabeth Schwendenwein 11 , Gérard Audibert 12 , Philippe Azouvi 13 , Maria Luisa Azzolini 14 , Luigi Beretta 14 , Maria Rosa Calvi 14 , Ronald Bartels 15 , Hugo den Boogert 15 , Pál Barzó 16 , Romuald Beauvais 17 , Natascha Perera 17 , Ronny Beer 18 , Raimund Helbok 18 , Bo-Michael Bellander 19 , Antonio Belli 20 , Habib Benali 21 , Vincent Degos 21 , Damien Galanaud 21 , Vincent Perlbarg 21 , Maurizio Berardino 22 , Simona Cavallo 22 , Morten Blaabjerg 23 , Christina Rosenlund 23 , Rico Frederik Schou 23 , Peter Bragge 24 , Alexandra Brazinova 25 , Marek Majdan 25 , Mark Steven Taylor 25 , Veronika Zelinkova 25 , Vibeke Brinck 26 , Mike Jarrett 26 , Joanne Brooker 27 , Emma Donoghue 27 , Anneliese Synnot 28 , Camilla Brorsson 29 , Lars-Owe Koskinen 29 , Nina Sundström 29 , Andras Buki 30 , Endre Czeiter 30 , Monika Bullinger 31 , Manuel Cabeleira 32 , Marek Czosnyka 32 , Abhishek Dixit 32 , Ari Ercole 32 , Evgenios Koraropoulos 32 , David Menon 32 , Virginia Newcombe 32 , Sophie Richter 32 , Peter Smielewski 32 , Emmanuel Stamatakis 32 , Guy Williams 32 , Stefan Winzeck 32 , Frederick A Zeiler 32 , Alessio Caccioppola 33 , Emiliana Calappi 33 , Marco Carbonara 33 , Fabrizio Ortolano 33 , Tommaso Zoerle 33 , Nino Stocchetti 34 , Peter Cameron 35 , Dashiell Gantner 35 , Lynnette Murray 35 , Tony Trapani 35 , Shirley Vallance 35 , Guillermo Carbayo Lozano 36 , Inigo Pomposo 36 , Ana M Castaño-León 37 , Pedro A Gomez 37 , Alfonso Lagares 37 , Giorgio Chevallard 38 , Arturo Chieregato 38 , Giuseppe Citerio 39 , Alessia Vargiolu 39 , Iris Ceyisakar 40 , Benjamin Gravesteijn 40 , Juanita A Haagsma 40 , Jilske Huijben 40 , Hester Lingsma 40 , Daan Nieboer 40 , Ana Mikolic 40 , Suzanne Polinder 40 , Charlie Sewalt 40 , Ewout W Steyerberg 41 , Kimberley Velt 40 , Daphne Voormolen 40 , Eveline Wiegers 40 , Wilco Peul 42 , Jeroen T J M van Dijck 42 , Thomas A van Essen 42 , Roel P J van Wijk 42 , Hans Clusmann 43 , Mark Coburn 44 , Ana Kowark 44 , Rolf Rossaint 44 , Jonathan Coles 45 , Jamie D Cooper 46 , Marta Correia 47 , Amra Cˇovid 48 , Nicole von Steinbüchel 48 , Nicola Curry 49 , Simon Stanworth 49 , Claire Dahyot-Fizelier 50 , Paul Dark 51 , Faye Johnson 51 , Helen Dawes 52 , Patrick Esser 52 , Caroline van Heugten 52 , Véronique De Keyser 53 , Andrew I R Maas 53 , Tomas Menovsky 53 , Gregory Van der Steen 53 , Francesco Della Corte 54 , Francesca Grossi 54 , Bart Depreitere 55 , Đula Đilvesi 56 , Jagoš Golubovic 56 , Mladen Karan 56 , Petar Vulekovic 56 , Jens Dreier 57 , Peter Vajkoczy 57 , Stefan Wolf 57 , Guy-Loup Dulière 58 , Hugues Maréchal 58 , Martin Fabricius 59 , Daniel Kondziella 59 , Valery L Feigin 60 , Kelly Jones 60 , Braden Te Ao 60 , Alice Theadom 60 , Kelly Foks 61 , Iain Haitsma 61 , Victor Volovici 61 , Alex Furmanov 62 , Guy Rosenthal 62 , Pablo Gagliardo 63 , Guoyi Gao 64 , Ji-Yao Jiang 64 , Alexandre Ghuysen 65 , Lelde Giga 66 , Egils Valeinis 66 , Agate Ziverte 66 , Ben Glocker 67 , Daniel Rueckert 67 , Johannes Gratz 68 , Russell L Gruen, Deepak Gupta 69 , Cecilie Roe, Eirik Helseth 70 , Olav Roise 70 , Lindsay Horton 71 , Lindsay Wilson 71 , Peter J Hutchinson 72 , Angelos G Kolias 72 , Bram Jacobs 73 , Joukje van der Naalt 73 , Stefan Jankowski 74 , Erwin Kompanje 75 , Marjolein Timmers 75 , Steven Laureys 76 , Didier Ledoux 76 , Benoit Misset 76 , Fiona Lecky 77 , Otesile Olubukola 78 , Rolf Lefering 79 , Nadine Schäfer 79 , Valerie Legrand 80 , Aurelie Lejeune 81 , Emmanuel Vega 81 , Julia Mattern 82 , Leon Levi 83 , Roger Lightfoot 84 , Marc Maegele 85 , Alex Manara 86 , Matt Thomas 86 , Geoffrey Manley 87 , Costanza Martino 88 , Oliver Sakowitz 89 , Renan Sanchez-Porras 90 , Alexander Younsi 91 , Catherine McMahon 92 , Ancuta Negru 93 , Matej Oresic 94 , Aarno Palotie 95 , Paul M Parizel 96 , Jean-François Payen 96 , Paolo Persona 97 , Anna Piippo-Karjalainen 98 , Matti Pirinen 99 , Horia Ples 93 , Jussi P Posti 100 , Louis Puybasset 101 , Andreea Radoi 102 , Arminas Ragauskas 103 , Rahul Raj 98 , Malinka Rambadagalla 104 , Jonathan Rhodes 105 , Sylvia Richardson 106 , Samuli Ripatti 99 , Saulius Rocka 103 , Jonathan Rosand 107 , Jeffrey V Rosenfeld 108 , Sandra Rossi 97 , Martin Rusnák 109 , Juan Sahuquillo 102 , Janos Sandor 110 , Silke Schmidt 111 , Herbert Schoechl 112 , Guus Schoonman 113 , Toril Skandsen 114 , Robert Stevens 115 , William Stewart 116 , Riikka Takala 100 , Tomas Tamosuitis 117 , Olli Tenovuo 100 , Dick Tibboel 118 , Christos Tolias 119 , Cristina Maria Tudora 93 , Mathieu van der Jagt 120 , Wim Van Hecke 121 , Dominique Van Praag 122 , Thijs Vande Vyvere 121 , Jan Verheyden 121 , Paul M Vespa 123 , Anne Vik 114 , Rimantas Vilcinis 117 , Kevin K W Wang 124 , Zhihui Yang 124 , Peter Ylén 125
Affiliations
- 1 Department of Public Health, Erasmus MC University Medical Center Rotterdam, P.O. Box 2040, Rotterdam, CA 3000, The Netherlands. Electronic address: m.vandervlegel@erasmusmc.nl.
- 2 Department of Public Health, Erasmus MC University Medical Center Rotterdam, P.O. Box 2040, Rotterdam, CA 3000, The Netherlands.
- 3 Department of Public Health, Erasmus MC University Medical Center Rotterdam, P.O. Box 2040, Rotterdam, CA 3000, The Netherlands; Department of Intensive Care Adults, Rotterdam, the Netherlands.
- 4 Department of Physical Medicine and Rehabilitation, Oslo University Hospital and University of Oslo, 0424 Oslo, Norway.
- 5 Institute of Medical Psychology and Medical Sociology, University Medical Center Göttingen (UMG)/ Georg-August-University, Göttingen, Germany.
- 6 Division of Psychology, University of Stirling, Stirling, UK.
- 7 Department of Neurosurgery, Antwerp University Hospital and University of Antwerp, Edegem, Belgium.
- 8 Karolinska Institutet, Stockholm, Sweden.
- 9 University of Pécs, Pécs, Hungary.
- 10 University Hospital Northern Norway, Tromso, Norway.
- 11 Medical University Vienna, Vienna, Austria.
- 12 University Hospital Nancy, Nancy, France.
- 13 Raymond Poincare Hospital, Assistance Publique - Hopitaux de Paris, Paris, France.
- 14 S. Raffaele University Hospital, Milan, Italy.
- 15 Radboud University Medical Center, Nijmegen, The Netherlands.
- 16 University of Szeged, Szeged, Hungary.
- 17 ARTTIC, Munchen, Germany.
- 18 Medical University of Innsbruck, Innsbruck, Austria.
- 19 Karolinska University Hospital, Stockholm, Sweden.
- 20 NIHR Surgical Reconstruction and Microbiology Research Centre, Birmingham, UK.
- 21 Assistance Publique - Hopitaux de Paris, Paris, France.
- 22 AOU Città della Salute e della Scienza di Torino - Orthopedic and Trauma Center, Torino, Italy.
- 23 Odense University Hospital, Odense, Denmark.
- 24 Monash University, Victoria, Australia.
- 25 Trnava University, Trnava, Slovakia.
- 26 Quesgen Systems Inc., Burlingame, California, USA.
- 27 Monash University, Melbourne, Australia.
- 28 Monash University, Melbourne, Australia; La Trobe University, Melbourne, Australia.
- 29 Umeå University, Umeå, Sweden.
- 30 University of Pécs, Hungary.
- 31 Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
- 32 University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
- 33 Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Italy.
- 34 Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Italy; Milan University.
- 35 Monash University, Melbourne, Victoria, Australia.
- 36 Hospital of Cruces, Bilbao, Spain.
- 37 Hospital Universitario 12 de Octubre, Madrid, Spain.
- 38 Niguarda Hospital, Milan, Italy.
- 39 ASST di Monza, Monza, Italy.
- 40 Erasmus Medical Center-University Medical Center, Rotterdam, The Netherlands.
- 41 Erasmus Medical Center-University Medical Center, Rotterdam, The Netherlands; Leiden University Medical Center, Leiden, The Netherlands.
- 42 Leiden University Medical Center, Leiden, The Netherlands; Medical Center Haaglanden, The Hague, The Netherlands.
- 43 Aachen University, Aachen, Germany.
- 44 University Hospital of Aachen, Aachen, Germany.
- 45 Cambridge University Hospital NHS Foundation Trust, Cambridge, UK.
- 46 Monash University and The Alfred Hospital, Melbourne, Victoria, Australia.
- 47 MRC Cognition and Brain Sciences Unit, Cambridge, UK.
- 48 Universitätsmedizin Göttingen, Göttingen, Germany.
- 49 Oxford University Hospitals NHS Trust, Oxford, UK.
- 50 CHU Poitiers, Potiers, France.
- 51 Salford Royal Hospital NHS Foundation Trust, Salford, UK.
- 52 Oxford Brookes University, Oxford, UK.
- 53 Antwerp University Hospital and University of Antwerp, Edegem, Belgium.
- 54 Maggiore Della Carità Hospital, Novara, Italy.
- 55 University Hospitals Leuven, Leuven, Belgium.
- 56 University of Novi Sad, Novi Sad, Serbia.
- 57 Charité - Universitätsmedizin Berlin, Berlin, Germany.
- 58 CHR Citadelle, Liège, Belgium.
- 59 Region Hovedstaden Rigshospitalet, Copenhagen, Denmark.
- 60 Auckland University of Technology, Auckland, New Zealand.
- 61 Erasmus MC, Rotterdam, the Netherlands.
- 62 Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
- 63 Fundación Instituto Valenciano de Neurorrehabilitación (FIVAN), Valencia, Spain.
- 64 Shanghai Renji Hospital, Shanghai Jiaotong University/School of Medicine, Shanghai, China.
- 65 CHU, Liège, Belgium.
- 66 Pauls Stradins Clinical University Hospital, Riga, Latvia.
- 67 Imperial College London, London, UK.
- 68 Medical University of Vienna, Austria.
- 69 All India Institute of Medical Sciences, New Delhi, India.
- 70 Oslo University Hospital, Oslo, Norway.
- 71 University of Stirling, Stirling, UK.
- 72 Addenbrooke's Hospital and University of Cambridge, Cambridge, UK.
- 73 University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
- 74 Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
- 75 Erasmus Medical Center, Rotterdam, The Netherlands.
- 76 University of Liège, Liège, Belgium.
- 77 University of Sheffield, Sheffield, UK; Salford Royal Hospital, Salford UK.
- 78 University of Sheffield, Sheffield, UK.
- 79 Witten/Herdecke University, Cologne, Germany.
- 80 ICON, Paris, France.
- 81 Lille University Hospital, Lille, France.
- 82 University Hospital Heidelberg, Heidelberg, Germany.
- 83 Rambam Medical Center, Haifa, Israel.
- 84 University Hospitals Southhampton NHS Trust, Southhampton, UK.
- 85 Cologne-Merheim Medical Center (CMMC), Witten/Herdecke University, Cologne, Germany.
- 86 Southmead Hospital, Bristol, UK.
- 87 University of California, San Francisco, California, USA.
- 88 M. Bufalini Hospital, Cesena, Italy.
- 89 University Hospital Heidelberg, Heidelberg, Germany; Klinik für Neurochirurgie, Klinikum Ludwigsburg, Ludwigsburg, Germany.
- 90 Klinik für Neurochirurgie, Klinikum Ludwigsburg, Ludwigsburg, Germany.
- 91 University of Manitoba, Winnipeg, MB, Canada.
- 92 The Walton Centre NHS Foundation Trust, Liverpool, UK.
- 93 Emergency County Hospital Timisoara, Timisoara, Romania.
- 94 Örebro University, Örebro, Sweden.
- 95 University of Helsinki, Helsinki, Finland; Massachusetts General Hospital, Boston, MA, USA; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
- 96 University Hospital of Grenoble, Grenoble, France.
- 97 Azienda Ospedaliera Università di Padova, Padova, Italy.
- 98 Helsinki University Central Hospital.
- 99 University of Helsinki, Helsinki, Finland.
- 100 Turku University Hospital and University of Turku, Turku, Finland.
- 101 Pitié -Salpêtrière Teaching Hospital, Assistance Publique, Hôpitaux de Paris and University Pierre et Marie Curie, Paris, France.
- 102 Vall d'Hebron Research Institute, Barcelona, Spain.
- 103 Kaunas University of Technology and Vilnius University, Vilnius, Lithuania.
- 104 Rezekne Hospital, Latvia.
- 105 NHS Lothian and University of Edinburg, Edinburgh, UK.
- 106 Cambridge Institute of Public Health, Cambridge, UK.
- 107 The Broad Institute, Cambridge MA Harvard Medical School and Massachusetts General Hospital, Boston MA, USA.
- 108 The Alfred Hospital, Monash University, Melbourne, Victoria, Australia.
- 109 International Neurotrauma Research Organisation, Vienna, Austria.
- 110 University of Debrecen, Debrecen, Hungary.
- 111 University Greifswald, Greifswald, Germany.
- 112 AUVA Trauma Hospital, Salzburg, Austria.
- 113 Elisabeth-Twee Steden Ziekenhuis, Tilburg, The Netherlands.
- 114 Norwegian University of Science and Technology, NTNU and St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
- 115 Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
- 116 Queen Elizabeth University Hospital and University of Glasgow, Glasgow, UK.
- 117 Kaunas University of Health Sciences, Kaunas, Lithuania.
- 118 Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.
- 119 Kings College London, London, UK.
- 120 Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands.
- 121 icoMetrix NV, Leuven, Belgium.
- 122 Antwerp University Hospital, Edegem, Belgium.
- 123 University of California, Los Angeles, California, USA.
- 124 University of Florida, Gainesville, Florida, USA.
- 125 VTT Technical Research Centre, Tampere, Finland.
- PMID: 35725508
- DOI: 10.1016/j.injury.2022.05.009
Item in Clipboard
Health care utilization and outcomes in older adults after Traumatic Brain Injury: A CENTER-TBI study
Marjolein van der Vlegel et al.
Injury.
2022 Aug.
Free article
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Format
doi: 10.1016/j.injury.2022.05.009.
Epub 2022 May 26.
Authors
Marjolein van der Vlegel
1
, Ana Mikolić
2
, Quentin Lee Hee
2
, Z L Rana Kaplan
2
, Isabel R A Retel Helmrich
2
, Ernest van Veen
3
, Nada Andelic
4
, Nicole V Steinbuechel
5
, Anne Marie Plass
5
, Marina Zeldovich
5
, Lindsay Wilson
6
, Andrew I R Maas
7
, Juanita A Haagsma
2
, Suzanne Polinder
2
; CENTER-TBI Participants and Investigators
Collaborators
-
CENTER-TBI Participants and Investigators:
Cecilia A Kerlund 8 , Pradeep George 8 , Linda Lanyon 8 , Visakh Muraleedharan 8 , David Nelson 8 , Krisztina Amrein 9 , Erzsébet Ezer 9 , Noémi Kovács 9 , Béla Melegh 9 , József Nyirádi 9 , Viktória Tamás 9 , Zoltán Vámos 9 , Abayomi Sorinola 9 , Nada Andelic, Lasse Andreassen 10 , Audny Anke 10 , Shirin Frisvold 10 , Anna Antoni 11 , Elisabeth Schwendenwein 11 , Gérard Audibert 12 , Philippe Azouvi 13 , Maria Luisa Azzolini 14 , Luigi Beretta 14 , Maria Rosa Calvi 14 , Ronald Bartels 15 , Hugo den Boogert 15 , Pál Barzó 16 , Romuald Beauvais 17 , Natascha Perera 17 , Ronny Beer 18 , Raimund Helbok 18 , Bo-Michael Bellander 19 , Antonio Belli 20 , Habib Benali 21 , Vincent Degos 21 , Damien Galanaud 21 , Vincent Perlbarg 21 , Maurizio Berardino 22 , Simona Cavallo 22 , Morten Blaabjerg 23 , Christina Rosenlund 23 , Rico Frederik Schou 23 , Peter Bragge 24 , Alexandra Brazinova 25 , Marek Majdan 25 , Mark Steven Taylor 25 , Veronika Zelinkova 25 , Vibeke Brinck 26 , Mike Jarrett 26 , Joanne Brooker 27 , Emma Donoghue 27 , Anneliese Synnot 28 , Camilla Brorsson 29 , Lars-Owe Koskinen 29 , Nina Sundström 29 , Andras Buki 30 , Endre Czeiter 30 , Monika Bullinger 31 , Manuel Cabeleira 32 , Marek Czosnyka 32 , Abhishek Dixit 32 , Ari Ercole 32 , Evgenios Koraropoulos 32 , David Menon 32 , Virginia Newcombe 32 , Sophie Richter 32 , Peter Smielewski 32 , Emmanuel Stamatakis 32 , Guy Williams 32 , Stefan Winzeck 32 , Frederick A Zeiler 32 , Alessio Caccioppola 33 , Emiliana Calappi 33 , Marco Carbonara 33 , Fabrizio Ortolano 33 , Tommaso Zoerle 33 , Nino Stocchetti 34 , Peter Cameron 35 , Dashiell Gantner 35 , Lynnette Murray 35 , Tony Trapani 35 , Shirley Vallance 35 , Guillermo Carbayo Lozano 36 , Inigo Pomposo 36 , Ana M Castaño-León 37 , Pedro A Gomez 37 , Alfonso Lagares 37 , Giorgio Chevallard 38 , Arturo Chieregato 38 , Giuseppe Citerio 39 , Alessia Vargiolu 39 , Iris Ceyisakar 40 , Benjamin Gravesteijn 40 , Juanita A Haagsma 40 , Jilske Huijben 40 , Hester Lingsma 40 , Daan Nieboer 40 , Ana Mikolic 40 , Suzanne Polinder 40 , Charlie Sewalt 40 , Ewout W Steyerberg 41 , Kimberley Velt 40 , Daphne Voormolen 40 , Eveline Wiegers 40 , Wilco Peul 42 , Jeroen T J M van Dijck 42 , Thomas A van Essen 42 , Roel P J van Wijk 42 , Hans Clusmann 43 , Mark Coburn 44 , Ana Kowark 44 , Rolf Rossaint 44 , Jonathan Coles 45 , Jamie D Cooper 46 , Marta Correia 47 , Amra Cˇovid 48 , Nicole von Steinbüchel 48 , Nicola Curry 49 , Simon Stanworth 49 , Claire Dahyot-Fizelier 50 , Paul Dark 51 , Faye Johnson 51 , Helen Dawes 52 , Patrick Esser 52 , Caroline van Heugten 52 , Véronique De Keyser 53 , Andrew I R Maas 53 , Tomas Menovsky 53 , Gregory Van der Steen 53 , Francesco Della Corte 54 , Francesca Grossi 54 , Bart Depreitere 55 , Đula Đilvesi 56 , Jagoš Golubovic 56 , Mladen Karan 56 , Petar Vulekovic 56 , Jens Dreier 57 , Peter Vajkoczy 57 , Stefan Wolf 57 , Guy-Loup Dulière 58 , Hugues Maréchal 58 , Martin Fabricius 59 , Daniel Kondziella 59 , Valery L Feigin 60 , Kelly Jones 60 , Braden Te Ao 60 , Alice Theadom 60 , Kelly Foks 61 , Iain Haitsma 61 , Victor Volovici 61 , Alex Furmanov 62 , Guy Rosenthal 62 , Pablo Gagliardo 63 , Guoyi Gao 64 , Ji-Yao Jiang 64 , Alexandre Ghuysen 65 , Lelde Giga 66 , Egils Valeinis 66 , Agate Ziverte 66 , Ben Glocker 67 , Daniel Rueckert 67 , Johannes Gratz 68 , Russell L Gruen, Deepak Gupta 69 , Cecilie Roe, Eirik Helseth 70 , Olav Roise 70 , Lindsay Horton 71 , Lindsay Wilson 71 , Peter J Hutchinson 72 , Angelos G Kolias 72 , Bram Jacobs 73 , Joukje van der Naalt 73 , Stefan Jankowski 74 , Erwin Kompanje 75 , Marjolein Timmers 75 , Steven Laureys 76 , Didier Ledoux 76 , Benoit Misset 76 , Fiona Lecky 77 , Otesile Olubukola 78 , Rolf Lefering 79 , Nadine Schäfer 79 , Valerie Legrand 80 , Aurelie Lejeune 81 , Emmanuel Vega 81 , Julia Mattern 82 , Leon Levi 83 , Roger Lightfoot 84 , Marc Maegele 85 , Alex Manara 86 , Matt Thomas 86 , Geoffrey Manley 87 , Costanza Martino 88 , Oliver Sakowitz 89 , Renan Sanchez-Porras 90 , Alexander Younsi 91 , Catherine McMahon 92 , Ancuta Negru 93 , Matej Oresic 94 , Aarno Palotie 95 , Paul M Parizel 96 , Jean-François Payen 96 , Paolo Persona 97 , Anna Piippo-Karjalainen 98 , Matti Pirinen 99 , Horia Ples 93 , Jussi P Posti 100 , Louis Puybasset 101 , Andreea Radoi 102 , Arminas Ragauskas 103 , Rahul Raj 98 , Malinka Rambadagalla 104 , Jonathan Rhodes 105 , Sylvia Richardson 106 , Samuli Ripatti 99 , Saulius Rocka 103 , Jonathan Rosand 107 , Jeffrey V Rosenfeld 108 , Sandra Rossi 97 , Martin Rusnák 109 , Juan Sahuquillo 102 , Janos Sandor 110 , Silke Schmidt 111 , Herbert Schoechl 112 , Guus Schoonman 113 , Toril Skandsen 114 , Robert Stevens 115 , William Stewart 116 , Riikka Takala 100 , Tomas Tamosuitis 117 , Olli Tenovuo 100 , Dick Tibboel 118 , Christos Tolias 119 , Cristina Maria Tudora 93 , Mathieu van der Jagt 120 , Wim Van Hecke 121 , Dominique Van Praag 122 , Thijs Vande Vyvere 121 , Jan Verheyden 121 , Paul M Vespa 123 , Anne Vik 114 , Rimantas Vilcinis 117 , Kevin K W Wang 124 , Zhihui Yang 124 , Peter Ylén 125
Affiliations
- 1 Department of Public Health, Erasmus MC University Medical Center Rotterdam, P.O. Box 2040, Rotterdam, CA 3000, The Netherlands. Electronic address: m.vandervlegel@erasmusmc.nl.
- 2 Department of Public Health, Erasmus MC University Medical Center Rotterdam, P.O. Box 2040, Rotterdam, CA 3000, The Netherlands.
- 3 Department of Public Health, Erasmus MC University Medical Center Rotterdam, P.O. Box 2040, Rotterdam, CA 3000, The Netherlands; Department of Intensive Care Adults, Rotterdam, the Netherlands.
- 4 Department of Physical Medicine and Rehabilitation, Oslo University Hospital and University of Oslo, 0424 Oslo, Norway.
- 5 Institute of Medical Psychology and Medical Sociology, University Medical Center Göttingen (UMG)/ Georg-August-University, Göttingen, Germany.
- 6 Division of Psychology, University of Stirling, Stirling, UK.
- 7 Department of Neurosurgery, Antwerp University Hospital and University of Antwerp, Edegem, Belgium.
- 8 Karolinska Institutet, Stockholm, Sweden.
- 9 University of Pécs, Pécs, Hungary.
- 10 University Hospital Northern Norway, Tromso, Norway.
- 11 Medical University Vienna, Vienna, Austria.
- 12 University Hospital Nancy, Nancy, France.
- 13 Raymond Poincare Hospital, Assistance Publique - Hopitaux de Paris, Paris, France.
- 14 S. Raffaele University Hospital, Milan, Italy.
- 15 Radboud University Medical Center, Nijmegen, The Netherlands.
- 16 University of Szeged, Szeged, Hungary.
- 17 ARTTIC, Munchen, Germany.
- 18 Medical University of Innsbruck, Innsbruck, Austria.
- 19 Karolinska University Hospital, Stockholm, Sweden.
- 20 NIHR Surgical Reconstruction and Microbiology Research Centre, Birmingham, UK.
- 21 Assistance Publique - Hopitaux de Paris, Paris, France.
- 22 AOU Città della Salute e della Scienza di Torino - Orthopedic and Trauma Center, Torino, Italy.
- 23 Odense University Hospital, Odense, Denmark.
- 24 Monash University, Victoria, Australia.
- 25 Trnava University, Trnava, Slovakia.
- 26 Quesgen Systems Inc., Burlingame, California, USA.
- 27 Monash University, Melbourne, Australia.
- 28 Monash University, Melbourne, Australia; La Trobe University, Melbourne, Australia.
- 29 Umeå University, Umeå, Sweden.
- 30 University of Pécs, Hungary.
- 31 Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
- 32 University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
- 33 Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Italy.
- 34 Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Italy; Milan University.
- 35 Monash University, Melbourne, Victoria, Australia.
- 36 Hospital of Cruces, Bilbao, Spain.
- 37 Hospital Universitario 12 de Octubre, Madrid, Spain.
- 38 Niguarda Hospital, Milan, Italy.
- 39 ASST di Monza, Monza, Italy.
- 40 Erasmus Medical Center-University Medical Center, Rotterdam, The Netherlands.
- 41 Erasmus Medical Center-University Medical Center, Rotterdam, The Netherlands; Leiden University Medical Center, Leiden, The Netherlands.
- 42 Leiden University Medical Center, Leiden, The Netherlands; Medical Center Haaglanden, The Hague, The Netherlands.
- 43 Aachen University, Aachen, Germany.
- 44 University Hospital of Aachen, Aachen, Germany.
- 45 Cambridge University Hospital NHS Foundation Trust, Cambridge, UK.
- 46 Monash University and The Alfred Hospital, Melbourne, Victoria, Australia.
- 47 MRC Cognition and Brain Sciences Unit, Cambridge, UK.
- 48 Universitätsmedizin Göttingen, Göttingen, Germany.
- 49 Oxford University Hospitals NHS Trust, Oxford, UK.
- 50 CHU Poitiers, Potiers, France.
- 51 Salford Royal Hospital NHS Foundation Trust, Salford, UK.
- 52 Oxford Brookes University, Oxford, UK.
- 53 Antwerp University Hospital and University of Antwerp, Edegem, Belgium.
- 54 Maggiore Della Carità Hospital, Novara, Italy.
- 55 University Hospitals Leuven, Leuven, Belgium.
- 56 University of Novi Sad, Novi Sad, Serbia.
- 57 Charité - Universitätsmedizin Berlin, Berlin, Germany.
- 58 CHR Citadelle, Liège, Belgium.
- 59 Region Hovedstaden Rigshospitalet, Copenhagen, Denmark.
- 60 Auckland University of Technology, Auckland, New Zealand.
- 61 Erasmus MC, Rotterdam, the Netherlands.
- 62 Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
- 63 Fundación Instituto Valenciano de Neurorrehabilitación (FIVAN), Valencia, Spain.
- 64 Shanghai Renji Hospital, Shanghai Jiaotong University/School of Medicine, Shanghai, China.
- 65 CHU, Liège, Belgium.
- 66 Pauls Stradins Clinical University Hospital, Riga, Latvia.
- 67 Imperial College London, London, UK.
- 68 Medical University of Vienna, Austria.
- 69 All India Institute of Medical Sciences, New Delhi, India.
- 70 Oslo University Hospital, Oslo, Norway.
- 71 University of Stirling, Stirling, UK.
- 72 Addenbrooke's Hospital and University of Cambridge, Cambridge, UK.
- 73 University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
- 74 Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
- 75 Erasmus Medical Center, Rotterdam, The Netherlands.
- 76 University of Liège, Liège, Belgium.
- 77 University of Sheffield, Sheffield, UK; Salford Royal Hospital, Salford UK.
- 78 University of Sheffield, Sheffield, UK.
- 79 Witten/Herdecke University, Cologne, Germany.
- 80 ICON, Paris, France.
- 81 Lille University Hospital, Lille, France.
- 82 University Hospital Heidelberg, Heidelberg, Germany.
- 83 Rambam Medical Center, Haifa, Israel.
- 84 University Hospitals Southhampton NHS Trust, Southhampton, UK.
- 85 Cologne-Merheim Medical Center (CMMC), Witten/Herdecke University, Cologne, Germany.
- 86 Southmead Hospital, Bristol, UK.
- 87 University of California, San Francisco, California, USA.
- 88 M. Bufalini Hospital, Cesena, Italy.
- 89 University Hospital Heidelberg, Heidelberg, Germany; Klinik für Neurochirurgie, Klinikum Ludwigsburg, Ludwigsburg, Germany.
- 90 Klinik für Neurochirurgie, Klinikum Ludwigsburg, Ludwigsburg, Germany.
- 91 University of Manitoba, Winnipeg, MB, Canada.
- 92 The Walton Centre NHS Foundation Trust, Liverpool, UK.
- 93 Emergency County Hospital Timisoara, Timisoara, Romania.
- 94 Örebro University, Örebro, Sweden.
- 95 University of Helsinki, Helsinki, Finland; Massachusetts General Hospital, Boston, MA, USA; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
- 96 University Hospital of Grenoble, Grenoble, France.
- 97 Azienda Ospedaliera Università di Padova, Padova, Italy.
- 98 Helsinki University Central Hospital.
- 99 University of Helsinki, Helsinki, Finland.
- 100 Turku University Hospital and University of Turku, Turku, Finland.
- 101 Pitié -Salpêtrière Teaching Hospital, Assistance Publique, Hôpitaux de Paris and University Pierre et Marie Curie, Paris, France.
- 102 Vall d'Hebron Research Institute, Barcelona, Spain.
- 103 Kaunas University of Technology and Vilnius University, Vilnius, Lithuania.
- 104 Rezekne Hospital, Latvia.
- 105 NHS Lothian and University of Edinburg, Edinburgh, UK.
- 106 Cambridge Institute of Public Health, Cambridge, UK.
- 107 The Broad Institute, Cambridge MA Harvard Medical School and Massachusetts General Hospital, Boston MA, USA.
- 108 The Alfred Hospital, Monash University, Melbourne, Victoria, Australia.
- 109 International Neurotrauma Research Organisation, Vienna, Austria.
- 110 University of Debrecen, Debrecen, Hungary.
- 111 University Greifswald, Greifswald, Germany.
- 112 AUVA Trauma Hospital, Salzburg, Austria.
- 113 Elisabeth-Twee Steden Ziekenhuis, Tilburg, The Netherlands.
- 114 Norwegian University of Science and Technology, NTNU and St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
- 115 Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
- 116 Queen Elizabeth University Hospital and University of Glasgow, Glasgow, UK.
- 117 Kaunas University of Health Sciences, Kaunas, Lithuania.
- 118 Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.
- 119 Kings College London, London, UK.
- 120 Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands.
- 121 icoMetrix NV, Leuven, Belgium.
- 122 Antwerp University Hospital, Edegem, Belgium.
- 123 University of California, Los Angeles, California, USA.
- 124 University of Florida, Gainesville, Florida, USA.
- 125 VTT Technical Research Centre, Tampere, Finland.
- PMID: 35725508
- DOI: 10.1016/j.injury.2022.05.009
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Abstract
Introduction: The incidence of Traumatic Brain Injury (TBI) is increasingly common in older adults aged ≥65 years, forming a growing public health problem. However, older adults are underrepresented in TBI research. Therefore, we aimed to provide an overview of health-care utilization, and of six-month outcomes after TBI and their determinants in older adults who sustained a TBI.
Methods: We used data from the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. In-hospital and post-hospital health care utilization and outcomes were described for patients aged ≥65 years. Ordinal and linear regression analyses were performed to identify determinants of the Glasgow Outcome Scale Extended (GOSE), health-related quality of life (HRQoL), and mental health symptoms six-months post-injury.
Results: Of 1254 older patients, 45% were admitted to an ICU with a mean length of stay of 9 days. Nearly 30% of the patients received inpatient rehabilitation. In total, 554/1254 older patients completed the six-month follow-up questionnaires. The mortality rate was 9% after mild and 60% after moderate/severe TBI, and full recovery based on GOSE was reported for 44% of patients after mild and 6% after moderate/severe TBI. Higher age and increased injury severity were primarily associated with functional impairment, while pre-injury systemic disease, psychiatric conditions and lower educational level were associated with functional impairment, lower generic and disease-specific HRQoL and mental health symptoms.
Conclusion: The rate of impairment and disability following TBI in older adults is substantial, and poorer outcomes across domains are associated with worse preinjury health. Nonetheless, a considerable number of patients fully or partially returns to their preinjury functioning. There should not be pessimism about outcomes in older adults who survive.
Keywords: Health care utilization; Health-related quality of life; Mental health; Older adults; Outcomes; Traumatic Brain Injury.
Copyright © 2022. Published by Elsevier Ltd.
Conflict of interest statement
Declaration of Competing Interest None.
