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Editorial
. 2022 Jul 29;145(7):2239-2241.
doi: 10.1093/brain/awac216.

Do genetic factors contribute to sex-specific differences in resilience to amyloid pathology?

Colin Groot  1   2   3 , Henne Holstege  1   2   4 , Rik Ossenkoppele  1   2   3
Affiliations
Editorial

Do genetic factors contribute to sex-specific differences in resilience to amyloid pathology?

Colin Groot et al. Brain. .

Abstract

This scientific commentary refers to ‘Sex differences in the genetic architecture of cognitive resilience to Alzheimer’s disease’ by Eissman et al. (https://doi.org/10.1093/brain/awac177).

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Figures

Figure 1
Figure 1
Overview of the study and key findings of Eissman and colleagues.
See this image and copyright information in PMC

Comment on

  • Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease.
    Eissman JM, Dumitrescu L, Mahoney ER, Smith AN, Mukherjee S, Lee ML, Scollard P, Choi SE, Bush WS, Engelman CD, Lu Q, Fardo DW, Trittschuh EH, Mez J, Kaczorowski CC, Hernandez Saucedo H, Widaman KF, Buckley RF, Properzi MJ, Mormino EC, Yang HS, Harrison TM, Hedden T, Nho K, Andrews SJ, Tommet D, Hadad N, Sanders RE, Ruderfer DM, Gifford KA, Zhong X, Raghavan NS, Vardarajan BN; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Alzheimer’s Disease Genetics Consortium (ADGC); A4 Study Team; Pericak-Vance MA, Farrer LA, Wang LS, Cruchaga C, Schellenberg GD, Cox NJ, Haines JL, Keene CD, Saykin AJ, Larson EB, Sperling RA, Mayeux R, Cuccaro ML, Bennett DA, Schneider JA, Crane PK, Jefferson AL, Hohman TJ. Eissman JM, et al. Brain. 2022 Jul 29;145(7):2541-2554. doi: 10.1093/brain/awac177. Brain. 2022. PMID: 35552371 Free PMC article.

References

    1. Beker N, Sikkes SAM, Hulsman M, et al. . Longitudinal maintenance of cognitive health in centenarians in the 100-plus study. JAMA Netw Open. 2020;3:e200094. - PMC - PubMed
    1. Tesi N, van der Lee SJ, Hulsman M, et al. . Centenarian controls increase variant effect sizes by an average twofold in an extreme case-extreme control analysis of Alzheimer's disease. Eur J Hum Genet. 2019;27:244–253. - PMC - PubMed
    1. Dumitrescu L, Mahoney ER, Mukherjee S, et al. . Genetic variants and functional pathways associated with resilience to Alzheimer's disease. Brain. 2020; 143:2561–2575. doi:10.1093/brain/awaa209 - DOI - PMC - PubMed
    1. Holstege H, Hulsman M, Charbonnier C, et al. . Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as novel risk factors for Alzheimer’s disease. medRxiv. [Preprint] doi:10.1101/2020.07.22.20159251 - DOI - PMC - PubMed
    1. Buckley RF, Scott MR, Jacobs HIL, et al. . Sex mediates relationships between regional tau pathology and cognitive decline. Ann Neurol. 2020;88:921–932. - PMC - PubMed