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. 2022 Jul;41(7):1093-1098.
doi: 10.1007/s10096-022-04466-9. Epub 2022 Jun 21.

Evaluation of a pneumonia multiplex PCR panel for detection of bacterial respiratory tract pathogens from serial specimens collected from hospitalized COVID-19 patients

Chaitanya Tellapragada  1 , Karin Andersson Ydsten  2 , Anders Ternhag  2   3 , Christian G Giske  4   5
Affiliations

Evaluation of a pneumonia multiplex PCR panel for detection of bacterial respiratory tract pathogens from serial specimens collected from hospitalized COVID-19 patients

Chaitanya Tellapragada et al. Eur J Clin Microbiol Infect Dis. 2022 Jul.

Abstract

We investigated the concordance between the Unyvero Hospitalized Pneumonia (HPN) application and quantitative culture for detection of bacterial pathogens from serial lower respiratory tract (LRT) specimens collected from the same subject. Comparison of results from HPN application and culture was evaluated using 69 LRT samples from 27 subjects, using two evaluation approaches. False positive detections by the HPN application was 29% (20/69) in Evaluation I vs 10% (7/68) in Evaluation II. Additional pathogens detected by the HPN application could be confirmed in many instances by culture positivity for the same organism from previous or subsequent samples from the same subject.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Distribution of the study samples based on their concordance and discordance with SoC results
See this image and copyright information in PMC

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