Expression of concern for

• Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease.

  Alfonso SI, Callender JA, Hooli B, Antal CE, Mullin K, Sherman MA, Lesné SE, Leitges M, Newton AC, Tanzi RE, Malinow R. Alfonso SI, et al. Sci Signal. 2016 May 10;9(427):ra47. doi: 10.1126/scisignal.aaf6209. Sci Signal. 2016. PMID: 27165780 Free PMC article.