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Comment
. 2022 Jun 20;57(12):1439-1441.
doi: 10.1016/j.devcel.2022.05.020.

Brief encounters: The relationship between enhancer proximity and gene expression

Helen Ray-Jones  1 , Mikhail Spivakov  2
Affiliations
Free article
Comment

Brief encounters: The relationship between enhancer proximity and gene expression

Helen Ray-Jones et al. Dev Cell. .
Free article

Abstract

In a recent issue of Nature, Zuin et al. (2022) integrate a transcriptional enhancer into various genomic locations surrounding a reporter gene promoter in order to determine how enhancer-promoter proximity affects gene expression. Their findings suggest a non-linear relationship, which the authors explain via a quantitative biophysical model with intriguing biological implications.

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Conflict of interest statement

Declaration of interests Mikhail Spivakov is a co-founder and shareholder of Enhanc3D Genomics Ltd.

Comment on

  • Nonlinear control of transcription through enhancer-promoter interactions.
    Zuin J, Roth G, Zhan Y, Cramard J, Redolfi J, Piskadlo E, Mach P, Kryzhanovska M, Tihanyi G, Kohler H, Eder M, Leemans C, van Steensel B, Meister P, Smallwood S, Giorgetti L. Zuin J, et al. Nature. 2022 Apr;604(7906):571-577. doi: 10.1038/s41586-022-04570-y. Epub 2022 Apr 13. Nature. 2022. PMID: 35418676 Free PMC article.

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