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Review
. 2022 Jul;1877(4):188752.
doi: 10.1016/j.bbcan.2022.188752. Epub 2022 Jun 18.

TGF-β, to target or not to target; to prevent thyroid cancer progression?

Isha Karnik  1 , Rachel Sutherland  1 , Joanna Elson  1 , Sebastian Aspinall  2 , Annette Meeson  3
Affiliations
Review

TGF-β, to target or not to target; to prevent thyroid cancer progression?

Isha Karnik et al. Biochim Biophys Acta Rev Cancer. 2022 Jul.

Abstract

Thyroid cancer (TC) is a common endocrine cancer with a rising incidence. Current treatment fails to eliminate aggressive thyroid tumours, prompting an investigation into the processes that cause disease progression. In this review, we provide insight into TGF-β driven epithelial to mesenchymal transition (EMT), summarizing the current literature surrounding thyroid carcinogenesis, and discuss the potential for therapeutic strategies targeting the TGF-β signalling pathway. Understanding the underlying mechanisms that regulate cancer stem cell (CSC) growth and TGF-β signalling may provide novel therapeutic approaches for highly resistant TCs.

Keywords: Epithelial to mesenchymal transition; Thyroid cancer; Transforming growth factor beta.

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