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Editorial
. 2022 Jul;33(7):1233-1235.
doi: 10.1681/ASN.2022040506. Epub 2022 Jun 21.

Predicting Future Outcomes from Kidney Biopsies with MCD/FSGS Lesions: Opportunities and Limitations

Hans-Joachim Anders  1 , Peter Boor  2
Affiliations
Editorial

Predicting Future Outcomes from Kidney Biopsies with MCD/FSGS Lesions: Opportunities and Limitations

Hans-Joachim Anders et al. J Am Soc Nephrol. 2022 Jul.
No abstract available

Keywords: focal segmental glomerulosclerosis; human genetics; nephrotic syndrome; pathophysiology of kidney disease and progression; proteinuria.

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Figures

Figure 1.
Figure 1.
The role of kidney biopsy in the diagnosis and prognosis prediction of podocytopathies. Kidney disease categories keep developing; this offers novel opportunities to overcome the hurdles related to MCD and FSGS, which are not diseases. Although defining a precise molecular diagnosis for these podocytopathies has remained challenging, whole-exome sequencing, together with reverse phenotyping for subtle manifestations of monogenic syndromal disorders and the identification of antinephrin antibodies as a cause for an autoimmune podocytopathy, offer promising possibilities for a definite diagnosis in the majority of patients. Prognosis prediction from histologic lesion patterns benefits from analyzing the biopsy at a high granularity and employing machine-learning tools. The future will be adding other diagnostic tools to predict prognosis (and define treatment) on the basis of identifying the underlying disease-causing podocyte injury.
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References

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