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Comment
. 2022 Aug;19(8):957-959.
doi: 10.1038/s41423-022-00889-8. Epub 2022 Jun 22.

ACPA-CD147 axis in the NLRP3 inflammasome of RA macrophages

Kui Zhang #  1   2 , Yan Zheng #  1   2 , Zhaohui Zheng #  1   2 , Ping Zhu  3   4
Affiliations
Comment

ACPA-CD147 axis in the NLRP3 inflammasome of RA macrophages

Kui Zhang et al. Cell Mol Immunol. 2022 Aug.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Double function of the ACPA-CD147 axis in NLRP3 inflammasome signaling in RA macrophages. Anti-citrullinated peptide/protein antibodies (ACPAs) from rheumatoid arthritis (RA) patients bind to the CD147-integrinβ1 complex on macrophages, which initiates two signals through its signaling pathways. In one pathway, the ACPA-CD147 axis primes the inflammasome signal through the PI3K-Akt pathway and results in high NLRP3 transcription. In the other pathway, the axis activates the inflammasome signal through the ATP-K+ efflux pathway and produces activated caspase-1 and IL-1β. Blocking the key molecule CD147 may stop these two signals to suppress the inflammasome
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References

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