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Review
. 2022 Aug;35(4):675-688.
doi: 10.1007/s10534-022-00406-4. Epub 2022 Jun 21.

Evolution of gallium applications in medicine and microbiology: a timeline

Amanda Stefanie Jabur de Assis  1   2 , Guilherme Manassés Pegoraro  3 , Iolanda Cristina Silveira Duarte  4
Affiliations
Review

Evolution of gallium applications in medicine and microbiology: a timeline

Amanda Stefanie Jabur de Assis et al. Biometals. 2022 Aug.

Abstract

Characterized as a semi-metal, gallium is a chemical element not found freely in the environment, but extracted as a by-product from other minerals. Despite of this, there are several gallium compounds with various applications, such as in the production of semiconductors, light emitting diodes; commercially as a potential cost reducer; pharmacology as cancer-related hypercalcemia, non-Hodgkin' lymphoma, breast and bladder cancer mainly and antimicrobial treatments. The latter will be emphasized in this work due to the contemporary emergence of the development of compounds with antimicrobial potential as a result of the spread of multidrug-resistant bacteria. So, this article discusses the main works, from the discovery of gallium to those that culminated in the current research in microbiology of the last two decades. The antimicrobial activity of gallium can be confirmed through the experimental data and be a promising mean to other investigations, especially due to its iron mimicry ability and the capacity to disrupt microorganisms' metabolism.

Keywords: Antimicrobial activity; Gallium; Medicine; Microbiology; Semi-metal.

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