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Comment
. 2022 Oct;38(10):1274-1276.
doi: 10.1007/s12264-022-00907-9. Epub 2022 Jun 21.

Microglia-Mediated Aβ Propagation in Alzheimer's Disease

Luoman Yang  1 , Shu Feng  2 , Chongyun Wu  2 , Luodan Yang  3
Affiliations
Comment

Microglia-Mediated Aβ Propagation in Alzheimer's Disease

Luoman Yang et al. Neurosci Bull. 2022 Oct.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing financial interests.

Figures

Fig. 1
Fig. 1
Microglia-mediated Aβ propagation in AD. In AD, microglia work as a carrier of amyloid to deliver Aβ into unaffected brain regions (wild-type neuron graft). Elimination of microglia or impaired microglial function attenuates Aβ propagation and slows plaque growth in the WT graft.
See this image and copyright information in PMC

Comment on

  • Microglia contribute to the propagation of Aβ into unaffected brain tissue.
    d'Errico P, Ziegler-Waldkirch S, Aires V, Hoffmann P, Mezö C, Erny D, Monasor LS, Liebscher S, Ravi VM, Joseph K, Schnell O, Kierdorf K, Staszewski O, Tahirovic S, Prinz M, Meyer-Luehmann M. d'Errico P, et al. Nat Neurosci. 2022 Jan;25(1):20-25. doi: 10.1038/s41593-021-00951-0. Epub 2021 Nov 22. Nat Neurosci. 2022. PMID: 34811521 Free PMC article.

References

    1. Wu CY, Yang LD, Tucker D, Dong Y, Zhu L, Duan R, et al. Beneficial effects of exercise pretreatment in a sporadic Alzheimer's rat model. Med Sci Sports Exerc. 2018;50:945–956. doi: 10.1249/MSS.0000000000001519. - DOI - PMC - PubMed
    1. Navarro V, Sanchez-Mejias E, Jimenez S, Muñoz-Castro C, Sanchez-Varo R, Davila JC, et al. Microglia in Alzheimer's disease: Activated, dysfunctional or degenerative. Front Aging Neurosci. 2018;10:140. doi: 10.3389/fnagi.2018.00140. - DOI - PMC - PubMed
    1. Wu CY, Yang LD, Youngblood H, Liu TCY, Duan R. Microglial SIRPα deletion facilitates synapse loss in preclinical models of neurodegeneration. Neurosci Bull. 2022;38:232–234. doi: 10.1007/s12264-021-00795-5. - DOI - PMC - PubMed
    1. Bohlen CJ, Friedman BA, Dejanovic B, Sheng M. Microglia in brain development, homeostasis, and neurodegeneration. Annu Rev Genet. 2019;53:263–288. doi: 10.1146/annurev-genet-112618-043515. - DOI - PubMed
    1. Lai AY, McLaurin J. Clearance of amyloid-β peptides by microglia and macrophages: The issue of what, when and where. Future Neurol. 2012;7:165–176. doi: 10.2217/fnl.12.6. - DOI - PMC - PubMed

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