Review of the effects and Mechanisms of microglial autophagy in ischemic stroke

Abstract

Stroke is a dysfunction caused by acute cerebrovascular disease, which has become the second leading cause of death in the world, resulting in a heavy burden on family and society. As a cellular adaptive mechanism, autophagy denoted a rather pivotal role in the process of ischemic stroke. Recent studies have suggested that autophagy of microglia has an important effect on polarization of phenotype and regulation of neuroinflammation, which implies that regulating autophagy of microglia may be a promising therapeutic strategy for the treatment of ischemic stroke. Therefore, this article explored the effects and signal pathways of microglial autophagy in ischemic stroke, aim to clarify the mechanism of autophagy of stroke, which will provide a reference for development of new targets for the treatment of ischemic stroke.

Keywords: AMPK; Autophagy; HIF-1α; Ischemic stroke; Microglia; PI3K/Akt.