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. 2022 Jul;28(7):1494-1498.
doi: 10.3201/eid2807.212505.

Determining Infected Aortic Aneurysm Treatment Using Focused Detection of Helicobacter cinaedi

Jien Saito, Emiko Rimbara, Shingo Inaguma, Chihiro Hasegawa, Shinji Kamiya, Akihiro Mizuno, Yoshiaki Sone, Tatsuhito Ogawa, Yukihide Numata, Satoru Takahashi, Miki Asano

Determining Infected Aortic Aneurysm Treatment Using Focused Detection of Helicobacter cinaedi

Jien Saito et al. Emerg Infect Dis. 2022 Jul.

Abstract

We detected Helicobacter cinaedi in 4 of 10 patients with infected aortic aneurysms diagnosed using blood or tissue culture in Aichi, Japan, during September 2017-January 2021. Infected aortic aneurysms caused by H. cinaedi had a higher detection rate and better results after treatment than previously reported, without recurrent infection.

Keywords: Helicobacter cinaedi; Japan; antimicrobial treatment; aortic aneurysm; arteriosclerosis; bacteria; infections.

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Figures

Figure 1
Figure 1
Contrast-enhanced computed tomography imaging for Case-patient 3 in the Helicobacter cinaedi group of 10 patients with infected aortic aneurysms with or without H. cinaedi, Aichi, Japan, September 2017–January 2021. A, B) The infrarenal aortic aneurysm had a maximum short diameter of 39 mm and a cystic protrusion of 19 mm (arrow in panel A) before the operation. C) After the operation, the adipose tissue concentration increased around the aneurysm (arrow).
Figure 2
Figure 2
Comparison of images from patients in the Helicobacter cinaedi group with patients from the non–H. cinaedi group among 10 patients with infected aortic aneurysms with or without H. cinaedi, Aichi, Japan, September 2017–January 2021. Immunohistochemistry was performed on the whole cell lysates of H. cinaedi strain MRY08-1234 isolated from immunocompromised patients in Japan by raising anti–rabbit H. cinaedi IgG. One of 2 case-patients with resected tissue in the H. cinaedi group had positive immunostaining (patient 1). A–C) Case-patient 1 in the H. cinaedi group. D–F) Case-patient 4 in the non–H. cinaedi group. In images from both patients, lymphocyte and neutrophil infiltrates, cholesterol clefts, foam cells, plasma cells, foreign body giant cells, and hemosiderin deposition are visible (A, B, D, E; hematoxylin & eosin). Immunohistochemistry stain shows of H. cinaedi organisms in the aortic intima (arrow in C) and negative results (F). Scale bars: 1,000 µm in A, D; 100 µm in B, E; 50 µm in C, F.
See this image and copyright information in PMC

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