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. 2022 Jul;28(7):1509-1512.
doi: 10.3201/eid2807.220642.

Natural Reassortment of Eurasian Avian-Like Swine H1N1 and Avian H9N2 Influenza Viruses in Pigs, China

Wanying Sun, Samuel S M Cheng, Kristy N T Lam, Tsz C Kwan, Ricky W K Wong, Leo H K Lau, Gigi Y Z Liu, Leo L H Luk, John K C Li, Haogao Gu, Malik Peiris, Leo L M Poon

Natural Reassortment of Eurasian Avian-Like Swine H1N1 and Avian H9N2 Influenza Viruses in Pigs, China

Wanying Sun et al. Emerg Infect Dis. 2022 Jul.

Abstract

Several zoonotic influenza A viruses detected in humans contain genes derived from avian H9N2 subtypes. We uncovered a Eurasian avian-like H1N1 swine influenza virus with polymerase basic 1 and matrix gene segments derived from the H9N2 subtype, suggesting that H9N2 viruses are infecting pigs and reassorting with swine influenza viruses in China.

Keywords: China; Eurasian avian-like swine H1N1 virus; avian H9N2 virus; influenza; pigs; viruses; zoonoses; zoonotic influenza A viruses.

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Figures

Figure
Figure
Phylogenetic tree of polymerase basic 1 (A) and matrix (B) gene sequences of swine influenza viruses from China and reference sequences. Bold indicates human H7N9 and H10N8 sequences. Viral sequences generated in this study (black circles) and those downloaded from public domains (Appendix Table) were aligned by using Muscle version 3.8 (http://www.drive5.com/muscle). Phylogenetic trees were constructed by IQ-TREE 1.6.12 (http://www.iqtree.org) by using the generalized time reversible plus gamma model. Major animal viral lineages are as shown. Bootstrap values ≥80% are shown. Scale bar indicates estimated genetic distance.
See this image and copyright information in PMC

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