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. 2022 Nov;279(11):5381-5387.
doi: 10.1007/s00405-022-07444-1. Epub 2022 Jun 22.

Prior cancer history predicts the worse survival of patients with nasopharyngeal carcinoma

Chien-Fu Yeh  1   2 , Yu-Ching Chin  1   2 , Wei-Hao Huang  1 , Ming-Ying Lan  3   4
Affiliations

Prior cancer history predicts the worse survival of patients with nasopharyngeal carcinoma

Chien-Fu Yeh et al. Eur Arch Otorhinolaryngol. 2022 Nov.

Abstract

Purpose: Previous cancers can be observed in patients with nasopharyngeal carcinoma (NPC). However, whether prior cancer diagnosis affects survival outcomes remains unknown. This study aimed to explore the impact of prior cancer on the survival of patients with NPC.

Methods: We retrospectively collected data from 666 NPC patients between 2006 and 2018. The patients in this study were divided into those without prior cancer, with prior head and neck cancer, and prior non-head and neck cancer. The demographic data and survival of these groups were then analyzed. The independent prognostic factors for NPC were determined using multivariate Cox regression analysis.

Results: We identified 25 NPC patients with prior cancer in our case series, most of whom had a history of colorectal cancer. Patients with a history of cancer were older than those without a history of cancer (p = 0.001). In the subgroup analysis stratified by the timing of prior cancer, NPC patients with prior non-head and neck cancer within 24, 36, 60, and 120 months showed worse survival than patients without prior cancer (all p < 0.05). When stratified by cancer stage, stage III NPC patients with prior non-head and neck cancer showed worse survival than patients without prior cancer (p < 0.001). Prior cancer and diabetes can predict worse survival in patients with stage III NPC.

Conclusion: This study demonstrated that prior cancer and diabetes are independent prognostic factors in patients with stage III NPC.

Keywords: Diabetes; Nasopharyngeal carcinoma; Prior cancer; Prognostic factors; Survival.

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References

    1. Chen YP, Chan ATC, Le QT, Blanchard P, Sun Y, Ma J (2019) Nasopharyngeal carcinoma. Lancet 394:64–80. https://doi.org/10.1016/S0140-6736(19)30956-0 - DOI - PubMed
    1. Blanchard P, Lee A, Marguet S et al (2015) Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update of the MAC-NPC meta-analysis. Lancet Oncol 16:645–655. https://doi.org/10.1016/S1470-2045(15)70126-9 - DOI - PubMed
    1. Leung TW, Tung SY, Sze WK et al (2005) Treatment results of 1070 patients with nasopharyngeal carcinoma: an analysis of survival and failure patterns. Head neck 27:555–565. https://doi.org/10.1002/hed.20189 - DOI - PubMed
    1. Kong F, Zhou J, Du C et al (2018) Long-term survival and late complications of intensity-modulated radiotherapy for recurrent nasopharyngeal carcinoma. BMC Cancer 18:1139. https://doi.org/10.1186/s12885-018-5055-5 - DOI - PubMed - PMC
    1. Wang WH, Yeh CF, Lan MY (2022) The role of nasopharyngectomy in the management of nasopharyngeal carcinoma. Curr Opin Otolaryngol Head Neck Surg 30:3–12. https://doi.org/10.1097/MOO.0000000000000780 - DOI - PubMed

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