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. 2022 Oct;24(10):375-383.
doi: 10.1007/s11906-022-01200-w. Epub 2022 Jun 22.

Blood Pressure Variability and Cognitive Function: a Scoping Review

Nur Fazidah Asmuje  1   2 , Sumaiyah Mat  3 , Phyo Kyaw Myint  4   5 , Maw Pin Tan  6   7   8
Affiliations

Blood Pressure Variability and Cognitive Function: a Scoping Review

Nur Fazidah Asmuje et al. Curr Hypertens Rep. 2022 Oct.

Abstract

Purpose of review: To conduct a scoping review of articles which have evaluated BPV and cognitive function. Articles with keywords, titles or abstracts containing the terms 'cognitive' OR 'cognition' OR 'dementia' AND 'blood pressure variability' were identified from CINAHL, Medline, PMC and Web of Science.

Recent findings: Methods of acquisition and analysis of BPV and cognitive measurements and their relationship were extracted from selected articles. Of 656 studies identified, 53 articles were selected. Twenty-five evaluated long-term (LTBPV), nine mid-term (MTBPV), 12 short-term (STBPV) and nine very short-term BPV (VSTBPV) with conflicting findings on the relationship between BPV and cognition. Variations existed in devices, period and procedure for acquisition. The studies also utilized a wide range of methods of BPV calculation. Thirteen cognitive assessment tools were used to measure global cognition or domain functions which were influenced by the population of interest. The interpretation of available studies was hence limited by heterogeneity. There is an urgent need for standardization of BPV assessments to streamline research on BPV and cognition. Future studies should also establish whether BPV could be a potential modifiable risk factor for cognitive decline, as well as a marker for treatment response.

Keywords: Aged; Blood pressure; Blood pressure variability; Cognition; Dementia.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
    1. Jaul E, Barron J. Age-related diseases and clinical and public health implications for the 85 years old and over population. Front Public Heal. 2017;5:1–7.
    1. •• Nagai M, Kario K. Visit-to-visit blood pressure variability: a possible marker of cognitive decline in Alzheimer’s Disease? Neurobiol Aging. 2015;36:1.
    1. Livingston G, Andrew S, Orgeta V, Costafreda SG, Huntley J, Ames D, et al. Dementia prevention, intervention, and care. The Lancet. 2017;390:2673–734.
    1. Turana Y, Tengkawan J, Chia YC, Hoshide S, Shin J, Chen CH, et al. Hypertension and dementia: a comprehensive review from the HOPE Asia Network”. J Clin Hypertens. 2019;21:1091–8.
    1. Tan MP. Standing up for frailty: blood pressure changes do matter. J Am Heart Assoc. 2020;9:7.

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