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. 2022 Jul 14;387(2):187-189.
doi: 10.1056/NEJMc2205276. Epub 2022 Jun 22.

Evaluation of Acute Adverse Events after Covid-19 Vaccination during Pregnancy

Malini DeSilva  1 , Jacob Haapala  1 , Gabriela Vazquez-Benitez  1 , Kimberly K Vesco  2 , Matthew F Daley  3 , Darios Getahun  4 , Ousseny Zerbo  5 , Allison Naleway  2 , Jennifer C Nelson  6 , Joshua T B Williams  7 , Simon J Hambidge  7 , Thomas G Boyce  8 , Candace C Fuller  9 , Heather S Lipkind  10 , Eric Weintraub  11 , Michael M McNeil  11 , Elyse O Kharbanda  12
Affiliations

Evaluation of Acute Adverse Events after Covid-19 Vaccination during Pregnancy

Malini DeSilva et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. Medically Attended Acute Adverse Events during Pregnancy, According to Receipt or Nonreceipt of a Covid-19 Vaccine (December 15, 2020–July 1, 2021).
Shown is the incidence of medically attended acute adverse events in 45,232 pregnant women who had received one or two doses of a Covid-19 vaccine immediately preceding or during pregnancy (78,026 vaccine doses) and unvaccinated matched controls. The rate of adverse events per 10,000 vaccine doses was calculated for the vaccinated women and was matched with the rate in an unvaccinated control. Data were evaluated within 21 days after vaccination at eight Vaccine Safety Datalink sites. There were no reports of a prespecified list of adverse events that included acute disseminated encephalomyelitis, cerebral venous sinus thrombosis, disseminated intravascular coagulation, encephalitis or myelitis, Guillain–Barré syndrome, myocarditis or pericarditis, hemorrhagic or ischemic stroke, Stevens–Johnson syndrome or toxic epidermal necrolysis, thrombosis with thrombocytopenia syndrome, transverse myelitis, thrombotic thrombocytopenic purpura, or pulmonary embolism. Anaphylaxis was evaluated only in the vaccinated group, and no confirmed cases were reported.
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Comment in

  • doi: 10.1056/NEJMe2206730

Comment on

  • doi: 10.1056/NEJMoa2204399

References

    1. Ellington S, Strid P, Tong VT, et al. Characteristics of women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status — United States, January 22–June 7, 2020. MMWR Morb Mortal Wkly Rep 2020;69:769-775. - PMC - PubMed
    1. Zambrano LD, Ellington S, Strid P, et al. Update: characteristics of symptomatic women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status — United States, January 22–October 3, 2020. MMWR Morb Mortal Wkly Rep 2020;69:1641-1647. - PMC - PubMed
    1. Centers for Disease Control and Prevention. COVID-19 vaccines while pregnant or breastfeeding. 2022. (https://www.cdc.gov/coronavirus/2019-ncov/vaccines/recommendations/pregn...).
    1. Theiler RN, Wick M, Mehta R, Weaver AL, Virk A, Swift M. Pregnancy and birth outcomes after SARS-CoV-2 vaccination in pregnancy. Am J Obstet Gynecol MFM 2021;3:100467-100467. - PMC - PubMed
    1. Groom HC, Crane B, Naleway AL, et al. Monitoring vaccine safety using the Vaccine Safety Datalink: assessing capacity to integrate data from Immunization Information Systems. Vaccine 2022;40:752-756. - PMC - PubMed

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