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Comment
. 2022 Jun 21;3(6):100669.
doi: 10.1016/j.xcrm.2022.100669.

TIL classified to memory state are correlated with response to immune checkpoint blockade

Inge Jedema  1 , John B Haanen  2
Affiliations
Comment

TIL classified to memory state are correlated with response to immune checkpoint blockade

Inge Jedema et al. Cell Rep Med. .

Abstract

Tumor reactivity mediated by tumor infiltrating lymphocytes (TILs) is one of the hallmarks of the clinical effect of immune checkpoint blockade (ICB). Jaiswal et al. used a functional genomics approach to better characterize TIL phenotypes predictive for response to ICB.1.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

References

    1. Jaiswal A., Verma A., Dannenfelser R., Melssen M., Tirosh I., Izar B., Kim T.G., Nirschl C.J., Devi K.S.P., Olson W.C., Jr., et al. An activation to memory differentiation trajectory of tumor-infiltrating lymphocytes informs metastatic melanoma outcomes. Cancer Cell. 2022;40:524–544.e5. doi: 10.1016/j.ccell.2022.04.005. - DOI - PMC - PubMed
    1. Gooden M.J.M., de Bock G.H., Leffers N., Daemen T., Nijman H.W. The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis. Br. J. Cancer. 2011;105:93–103. doi: 10.1038/bjc.2011.189. - DOI - PMC - PubMed
    1. Rohaan M.W., van den Berg J.H., Kvistborg P., Haanen J.B.A.G. Adoptive transfer of tumor-infiltrating lymphocytes in melanoma: a viable treatment option. J Immunother Cancer. 2018;6:102. doi: 10.1186/s40425-018-0391-1. - DOI - PMC - PubMed
    1. Wherry E.J., Ha S.J., Kaech S.M., Haining W.N., Sarkar S., Kalia V., Subramaniam S., Blattman J.N., Barber D.L., Ahmed R. Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity. 2007;27:670–684. doi: 10.1016/j.immuni.2007.09.006. - DOI - PubMed
    1. Schietinger A., Philip M., Krisnawan V.E., Chiu E.Y., Delrow J.J., Basom R.S., Lauer P., Brockstedt D.G., Knoblaugh S.E., Hämmerling G.J., et al. Tumor-specific T cell dysfunction is a Dynamic antigen-Driven differentiation program Initiated early during Tumorigenesis. Immunity. 2016;45:389–401. doi: 10.1016/j.immuni.2016.07.011. - DOI - PMC - PubMed

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