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. 2022 Sep 2;31(9):1710-1719.
doi: 10.1158/1055-9965.EPI-22-0210.

Ethnic Disparities in Early-Onset Gastric Cancer: A Population-Based Study in Texas and California

Anna Tavakkoli  1   2   3 , Sandi L Pruitt  2   3 , Anh Q Hoang  4 , Hong Zhu  3 , Amy E Hughes  2   3 , Thomas A McKey  2 , B Joseph Elmunzer  5 , Richard S Kwon  6 , Caitlin C Murphy #  7 , Amit G Singal #  1   2   3
Affiliations

Ethnic Disparities in Early-Onset Gastric Cancer: A Population-Based Study in Texas and California

Anna Tavakkoli et al. Cancer Epidemiol Biomarkers Prev. .

Abstract

Background: Incidence rates of gastric cancer are increasing in young adults (age <50 years), particularly among Hispanic persons. We estimated incidence rates of early-onset gastric cancer (EOGC) among Hispanic and non-Hispanic White persons by census tract poverty level and county-level metro/nonmetro residence.

Methods: We used population-based data from the California and Texas Cancer Registries from 1995 to 2016 to estimate age-adjusted incidence rates of EOGC among Hispanic and non-Hispanic White persons by year, sex, tumor stage, census tract poverty level, metro versus nonmetro county, and state. We used logistic regression models to identify factors associated with distant stage diagnosis.

Results: Of 3,047 persons diagnosed with EOGC, 73.2% were Hispanic White. Incidence rates were 1.29 [95% confidence interval (CI), 1.24-1.35] and 0.31 (95% CI, 0.29-0.33) per 100,000 Hispanic White and non-Hispanic White persons, respectively, with consistently higher incidence rates among Hispanic persons at all levels of poverty. There were no statistically significant associations between ethnicity and distant stage diagnosis in adjusted analysis.

Conclusions: There are ethnic disparities in EOGC incidence rates that persist across poverty levels.

Impact: EOGC incidence rates vary by ethnicity and poverty; these factors should be considered when assessing disease risk and targeting prevention efforts.

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Conflict of interest statement

Conflicts of Interest:

1. Dr. Caitlin C. Murphy discloses consulting fees for Freenome.

2. The remaining authors disclose no potential conflicts of interest.

Figures

Figure 1:
Figure 1:
Eligible Patients in the Texas and California Cancer Registry
Figure 2:
Figure 2:
Annual Percent Change Among Hispanic and Non-Hispanic Whites with Early-Onset Gastric Cancer (EOGC) A. Annual Percent Change of EOGC from 1995–2016 by Ethnicity B. Annual Percent Change of EOGC from 1995–2016 by Ethnicity and Stage of Disease
See this image and copyright information in PMC

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