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. 2022 Oct 19;107(11):1043-1045.
doi: 10.1136/archdischild-2021-323686.

Advanced chronic kidney disease among UK children

Lucy Plumb  1   2 , Winnie Magadi  3 , Anna Casula  3 , Ben C Reynolds  4 , Mairead Convery  5 , Shuman Haq  6 , Shivaram Hegde  7 , Andrew Lunn  8 , Michal Malina  9   10 , Henry Morgan  11 , Mordi Muorah  12 , Kay Tyerman  13 , Manish D Sinha  14 , Dean Wallace  15 , Carol Inward  16 , Stephen Marks  17   18 , Dorothea Nitsch  3   19 , James Medcalf  3   20
Affiliations

Advanced chronic kidney disease among UK children

Lucy Plumb et al. Arch Dis Child. .

Abstract

The UK Renal Registry currently collects information on UK children with kidney failure requiring long-term kidney replacement therapy (KRT), which supports disease surveillance and auditing of care and outcomes; however, data are limited on children with chronic kidney disease (CKD) not on KRT.

Methods: In March 2020, all UK Paediatric Nephrology centres submitted data on children aged <16 years with severely reduced kidney function as of December 2019, defined as an estimated glomerular filtration rate <30 mL/min/1.73 m2.

Results: In total, 1031 children had severe CKD, the majority of whom (80.7%) were on KRT. The overall prevalence was 81.2 (95% CI 76.3 to 86.3) per million of the age-related population.

Conclusions: The prevalence of severe CKD among UK children is largely due to a high proportion of children on long-term KRT. Expanding data capture to include children with CKD before reaching failure will provide greater understanding of the CKD burden in childhood.

Keywords: Epidemiology; Nephrology; Paediatrics.

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Conflict of interest statement

Competing interests: LP declares funding from the National Institute for Health Research (NIHR) and Kidney Research UK (KRUK). BCR declares funding from KRUK, honoraria from Alexion Pharmaceuticals and Magnolia Innovation, and consultancy payment from Chiesi. MM reports previous honoraria and travel expenses from Alexion. SM declares a role as head of the UK Renal Registry Audit and Informatics group. KT declares a role as clinical lead of the National Institute for Health and Care Excellence Medical Technologies Advisory Committee during the study period. DN declares funding/payment from the Health Foundation, UK Kidney Association, Chiang Mai University and GSK.

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