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Randomized Controlled Trial
. 2022 Jun 22;12(1):33.
doi: 10.1038/s41387-022-00210-6.

Folic acid effect on homocysteine, sortilin levels and glycemic control in type 2 diabetes mellitus patients

Noha M El-Khodary  1 , Hossam Dabees  2 , Rehab H Werida  3
Affiliations
Randomized Controlled Trial

Folic acid effect on homocysteine, sortilin levels and glycemic control in type 2 diabetes mellitus patients

Noha M El-Khodary et al. Nutr Diabetes. .

Abstract

Aim: The present study aimed to determine the folic acid supplement (FAS) effects on serum homocysteine and sortilin levels, glycemic indices, and lipid profile in type II diabetic patients.

Method: A double-blind randomized controlled clinical trial have been performed on 100 patients with T2DM randomly divided into two groups that received either placebo or folic acid 5 mg/d for 12 weeks.

Results: FAS caused a significant decrease in homocysteine and sortilin serum levels (28.2% and 33.7%, P < 0.0001, respectively). After 3 months of intervention, 8.7% decrease in fasting blood glucose (P = 0.0005), 8.2% in HbA1c (P = 0.0002), 13.7% in serum insulin (P < 0.0001) and 21.7% in insulin resistance (P < 0.0001) were found in the folic acid group, however no significant difference was observed in the placebo group. Serum hs-CRP level showed significant positive associations with sortilin (r = 0.237, P = 0.018), homocysteine (r = 0.308, P = 0.002) and fasting blood glucose (r = 0.342, P = 0.000). There were no significant changes in lipid profile in both groups after 12 weeks.

Conclusion: FAS might be beneficial for reducing homocysteine and sortilin levels, enhancing glycemic control, and improved insulin resistance in patients with T2DM.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
CONSORT flowchart of the study.
Fig. 2
Fig. 2. Changes in the measured variables (A) Homocysteine (B) Sortilin (C) hs-CRP.
‡Paired sample t-test statistically significant within groups at P< 0.05. *Independent sample t-test statistically significant between groups at P < 0.05.
Fig. 3
Fig. 3
Area under ROC curve of the determined parameters.
See this image and copyright information in PMC

References

    1. Huang T, Asimi S, Lou D, Li D. Plasma phospholipid polyunsaturated fatty acids and homocysteine in Chinese type 2 diabetes patients. Asia Pac J Clin Nutr. 2012;21:394. - PubMed
    1. Chokrungvaranon N, Deer J, Reaven PD. Intensive glycemic control and cardiovascular disease: are there patients who may benefit? Postgrad Med. 2011;123:114–23. doi: 10.3810/pgm.2011.11.2501. - DOI - PubMed
    1. Sudchada P, Saokaew S, Sridetch S, Incampa S, Jaiyen S, Khaithong W. Effect of folic acid supplementation on plasma total homocysteine levels and glycemic control in patients with type 2 diabetes: a systematic review and meta-analysis. Diabetes Res Clin Pr. 2012;98:151–8. doi: 10.1016/j.diabres.2012.05.027. - DOI - PubMed
    1. Li Y, Huang T, Zheng Y, Muka T, Troup J, Hu FB. Folic acid supplementation and the risk of cardiovascular diseases: a meta‐analysis of randomized controlled trials. J Am Heart Assoc. 2016;5:e003768. doi: 10.1161/JAHA.116.003768. - DOI - PMC - PubMed
    1. Werida RH, Omran A, El-Khodary NM. Sortilin and Homocysteine as Potential Biomarkers for Coronary Artery Diseases. Int J Gen Med. 2021;14:6167. doi: 10.2147/IJGM.S324889. - DOI - PMC - PubMed

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