The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms

Rita Alaggio¹, Catalina Amador², Ioannis Anagnostopoulos³, Ayoma D Attygalle⁴, Iguaracyra Barreto de Oliveira Araujo⁵, Emilio Berti⁶, Govind Bhagat⁷, Anita Maria Borges⁸, Daniel Boyer⁹, Mariarita Calaminici¹⁰, Amy Chadburn¹¹, John K C Chan¹², Wah Cheuk¹², Wee-Joo Chng¹³, John K Choi¹⁴, Shih-Sung Chuang¹⁵, Sarah E Coupland¹⁶, Magdalena Czader¹⁷, Sandeep S Dave¹⁸, Daphne de Jong¹⁹, Ming-Qing Du²⁰, Kojo S Elenitoba-Johnson²¹, Judith Ferry²², Julia Geyer¹¹, Dita Gratzinger²³, Joan Guitart²⁴, Sumeet Gujral²⁵, Marian Harris²⁶, Christine J Harrison²⁷, Sylvia Hartmann²⁸, Andreas Hochhaus²⁹, Patty M Jansen³⁰, Kennosuke Karube³¹, Werner Kempf³², Joseph Khoury³³, Hiroshi Kimura³⁴, Wolfram Klapper³⁵, Alexandra E Kovach³⁶, Shaji Kumar³⁷, Alexander J Lazar³⁸, Stefano Lazzi³⁹, Lorenzo Leoncini³⁹, Nelson Leung⁴⁰, Vasiliki Leventaki⁴¹, Xiao-Qiu Li⁴², Megan S Lim²¹, Wei-Ping Liu⁴³, Abner Louissaint Jr⁴⁴, Andrea Marcogliese⁴⁵, L Jeffrey Medeiros³³, Michael Michal⁴⁶, Roberto N Miranda³³, Christina Mitteldorf⁴⁷, Santiago Montes-Moreno⁴⁸, William Morice⁴⁹, Valentina Nardi⁴⁴, Kikkeri N Naresh⁵⁰, Yasodha Natkunam²³, Siok-Bian Ng⁵¹, Ilske Oschlies³⁵, German Ott⁵², Marie Parrens⁵³, Melissa Pulitzer⁵⁴, S Vincent Rajkumar⁵⁵, Andrew C Rawstron⁵⁶, Karen Rech⁴⁹, Andreas Rosenwald³, Jonathan Said⁵⁷, Clémentine Sarkozy⁵⁸, Shahin Sayed⁵⁹, Caner Saygin⁶⁰, Anna Schuh⁶¹, William Sewell⁶², Reiner Siebert⁶³, Aliyah R Sohani⁴⁴, Reuben Tooze⁶⁴, Alexandra Traverse-Glehen⁶⁵, Francisco Vega³³, Beatrice Vergier⁶⁶, Ashutosh D Wechalekar⁶⁷, Brent Wood³⁶, Luc Xerri⁶⁸, Wenbin Xiao⁵⁴

Affiliations

¹ Pathology Unit, Department of Laboratories, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy.
² Department of Pathology, University of Miami, Miami, FL, USA.
³ Institute of Pathology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.
⁴ Department of Histopathology, Royal Marsden Hospital, London, UK.
⁵ Department of Pathology, Federal University of Bahia (UFBA), Salvador, Brazil.
⁶ University of Milan, Fondazione Cà Granda, IRCCS, Ospedale Maggiore Policlinico, Milan, Italy.
⁷ Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.
⁸ Division of Histopathology, SL Raheja Hospital, Mumbai, India.
⁹ Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
¹⁰ Centre for Haemato-Oncology, Barts Cancer institute, QMUL and SIHMDS Barts Health NHS Trust, London, UK.
¹¹ Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
¹² Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong.
¹³ National University Cancer Institute, Singapore, Singapore.
¹⁴ Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL, USA.
¹⁵ Department of Pathology, Chi-Mei Medical Center, Tainan, Taiwan.
¹⁶ Liverpool Clinical Laboratories, Liverpool University Hospitals Foundation Trust, Liverpool, UK.
¹⁷ Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA.
¹⁸ Center for Genomic and Computational Biology and Department of Medicine, Duke University, Durham, NC, USA.
¹⁹ Amsterdam UMC, location Vrije Universiteit Amsterdam, Department of Pathology, Amsterdam, The Netherlands.
²⁰ Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK. mqd20@cam.ac.uk.
²¹ Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
²² Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. JFERRY@mgh.harvard.edu.
²³ Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
²⁴ Department. of Dermatology, Northwestern University Feinberg Medical School, Chicago, IL, USA.
²⁵ Department of Pathology, Tata Memorial Hospital, Mumbai, India.
²⁶ Department of Pathology, Boston Children's Hospital, Boston, MA, USA.
²⁷ Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle-upon-Tyne, UK.
²⁸ Dr. Senckenberg Institute of Pathology, Goethe University Frankfurt, Frankfurt am Main, Germany.
²⁹ Hematology/Oncology, Universitätsklinikum Jena, Jena, Germany.
³⁰ Leiden University Medical Center, Department of Pathology, Leiden, The Netherlands.
³¹ Department of Pathology and Laboratory Medicine, Nagoya, Japan.
³² Kempf und Pfaltz Histologische Diagnostik Zurich, and Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
³³ Department of Hematopathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
³⁴ Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
³⁵ Department of Pathology, Hematopathology Section and Lymph Node Registry, University Hospital Schleswig-Holstein, University of Kiel, Kiel, Germany.
³⁶ Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.
³⁷ Division of Hematology, Mayo Clinic, Rochester, MN, USA.
³⁸ Departments of Pathology & Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
³⁹ Department of Medical Biotechnology, University of Siena, Siena, Italy.
⁴⁰ Division of Nephrology and Hypertension, Division of Hematology, Mayo Clinic, Rochester, MN, USA.
⁴¹ Department of Pathology, Medical College of Wisconsin and Children's Wisconsin, Milwaukee, WI, USA.
⁴² Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.
⁴³ Department of Pathology, West-China Hospital, Sichuan University, Chengdu, China.
⁴⁴ Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
⁴⁵ Department of Pathology & Immunology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
⁴⁶ Department of Pathology, Charles University in Prague, Faculty of Medicine in Plzen, Plzen, Czech Republic.
⁴⁷ Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany.
⁴⁸ Anatomic Pathology Department and Translational Hematopathology Lab, Valdecilla/IDIVAL University Hospital, Santander, Spain.
⁴⁹ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
⁵⁰ Section of Pathology, Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
⁵¹ Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
⁵² Department of Clinical Pathology, Robert-Bosch-Krankenhaus, and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany. German.Ott@rbk.de.
⁵³ Department of Pathology, Bordeaux University Hospital, Bordeaux, France.
⁵⁴ Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
⁵⁵ Division of Hematology, Mayo Clinic, Rochester, Minnesota, Rochester, MN, USA.
⁵⁶ HMDS, Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
⁵⁷ Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA, USA.
⁵⁸ MD-PhD, DITEP, Gustave Roussy, Villejuif, France.
⁵⁹ Department of Pathology- Aga Khan University Hospital- Nairobi, Nairobi, Kenya.
⁶⁰ Section of Hematology/Oncology, University of Chicago, Chicago, IL, USA.
⁶¹ Department of Oncology, University of Oxford, Oxford, UK.
⁶² Immunology Division, Garvan Institute of Medical Research, Sydney, Australia.
⁶³ Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany. reiner.siebert@uni-ulm.de.
⁶⁴ Division of Haematology and Immunology, Leeds Institute of Medical Research, University of Leeds, Leeds, UK.
⁶⁵ Hospices Civils de Lyon/Department of Pathology/ Université Lyon 1/ Centre International de Recherche en Infectiologie (CIRI) INSERM U1111 -, CNRS UMR5308, Lyon, France.
⁶⁶ Department of Pathology, Hopital Haut-Lévêque, CHU Bordeaux, Pessac, France.
⁶⁷ National Amyloidosis Centre, University College London, London, UK.
⁶⁸ Department of Pathology, Institut Paoli-Calmettes and Aix-Marseillreference University, Marseille, France.

PMID: 35732829
PMCID: PMC9214472
DOI: 10.1038/s41375-022-01620-2

Free PMC article

Review

The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms

Rita Alaggio et al. Leukemia. 2022 Jul.

Free PMC article

. 2022 Jul;36(7):1720-1748.

doi: 10.1038/s41375-022-01620-2. Epub 2022 Jun 22.

Authors

Affiliations

¹ Pathology Unit, Department of Laboratories, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy.
² Department of Pathology, University of Miami, Miami, FL, USA.
³ Institute of Pathology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.
⁴ Department of Histopathology, Royal Marsden Hospital, London, UK.
⁵ Department of Pathology, Federal University of Bahia (UFBA), Salvador, Brazil.
⁶ University of Milan, Fondazione Cà Granda, IRCCS, Ospedale Maggiore Policlinico, Milan, Italy.
⁷ Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.
⁸ Division of Histopathology, SL Raheja Hospital, Mumbai, India.
⁹ Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
¹⁰ Centre for Haemato-Oncology, Barts Cancer institute, QMUL and SIHMDS Barts Health NHS Trust, London, UK.
¹¹ Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
¹² Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong.
¹³ National University Cancer Institute, Singapore, Singapore.
¹⁴ Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL, USA.
¹⁵ Department of Pathology, Chi-Mei Medical Center, Tainan, Taiwan.
¹⁶ Liverpool Clinical Laboratories, Liverpool University Hospitals Foundation Trust, Liverpool, UK.
¹⁷ Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA.
¹⁸ Center for Genomic and Computational Biology and Department of Medicine, Duke University, Durham, NC, USA.
¹⁹ Amsterdam UMC, location Vrije Universiteit Amsterdam, Department of Pathology, Amsterdam, The Netherlands.
²⁰ Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK. mqd20@cam.ac.uk.
²¹ Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
²² Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. JFERRY@mgh.harvard.edu.
²³ Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
²⁴ Department. of Dermatology, Northwestern University Feinberg Medical School, Chicago, IL, USA.
²⁵ Department of Pathology, Tata Memorial Hospital, Mumbai, India.
²⁶ Department of Pathology, Boston Children's Hospital, Boston, MA, USA.
²⁷ Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle-upon-Tyne, UK.
²⁸ Dr. Senckenberg Institute of Pathology, Goethe University Frankfurt, Frankfurt am Main, Germany.
²⁹ Hematology/Oncology, Universitätsklinikum Jena, Jena, Germany.
³⁰ Leiden University Medical Center, Department of Pathology, Leiden, The Netherlands.
³¹ Department of Pathology and Laboratory Medicine, Nagoya, Japan.
³² Kempf und Pfaltz Histologische Diagnostik Zurich, and Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
³³ Department of Hematopathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
³⁴ Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
³⁵ Department of Pathology, Hematopathology Section and Lymph Node Registry, University Hospital Schleswig-Holstein, University of Kiel, Kiel, Germany.
³⁶ Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.
³⁷ Division of Hematology, Mayo Clinic, Rochester, MN, USA.
³⁸ Departments of Pathology & Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
³⁹ Department of Medical Biotechnology, University of Siena, Siena, Italy.
⁴⁰ Division of Nephrology and Hypertension, Division of Hematology, Mayo Clinic, Rochester, MN, USA.
⁴¹ Department of Pathology, Medical College of Wisconsin and Children's Wisconsin, Milwaukee, WI, USA.
⁴² Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.
⁴³ Department of Pathology, West-China Hospital, Sichuan University, Chengdu, China.
⁴⁴ Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
⁴⁵ Department of Pathology & Immunology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
⁴⁶ Department of Pathology, Charles University in Prague, Faculty of Medicine in Plzen, Plzen, Czech Republic.
⁴⁷ Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany.
⁴⁸ Anatomic Pathology Department and Translational Hematopathology Lab, Valdecilla/IDIVAL University Hospital, Santander, Spain.
⁴⁹ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
⁵⁰ Section of Pathology, Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
⁵¹ Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
⁵² Department of Clinical Pathology, Robert-Bosch-Krankenhaus, and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany. German.Ott@rbk.de.
⁵³ Department of Pathology, Bordeaux University Hospital, Bordeaux, France.
⁵⁴ Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
⁵⁵ Division of Hematology, Mayo Clinic, Rochester, Minnesota, Rochester, MN, USA.
⁵⁶ HMDS, Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
⁵⁷ Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA, USA.
⁵⁸ MD-PhD, DITEP, Gustave Roussy, Villejuif, France.
⁵⁹ Department of Pathology- Aga Khan University Hospital- Nairobi, Nairobi, Kenya.
⁶⁰ Section of Hematology/Oncology, University of Chicago, Chicago, IL, USA.
⁶¹ Department of Oncology, University of Oxford, Oxford, UK.
⁶² Immunology Division, Garvan Institute of Medical Research, Sydney, Australia.
⁶³ Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany. reiner.siebert@uni-ulm.de.
⁶⁴ Division of Haematology and Immunology, Leeds Institute of Medical Research, University of Leeds, Leeds, UK.
⁶⁵ Hospices Civils de Lyon/Department of Pathology/ Université Lyon 1/ Centre International de Recherche en Infectiologie (CIRI) INSERM U1111 -, CNRS UMR5308, Lyon, France.
⁶⁶ Department of Pathology, Hopital Haut-Lévêque, CHU Bordeaux, Pessac, France.
⁶⁷ National Amyloidosis Centre, University College London, London, UK.
⁶⁸ Department of Pathology, Institut Paoli-Calmettes and Aix-Marseillreference University, Marseille, France.

PMID: 35732829
PMCID: PMC9214472
DOI: 10.1038/s41375-022-01620-2

Erratum in

Correction: "The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms" Leukemia. 2022 Jul;36(7):1720-1748.
Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, de Oliveira Araujo IB, Berti E, Bhagat G, Borges AM, Boyer D, Calaminici M, Chadburn A, Chan JKC, Cheuk W, Chng WJ, Choi JK, Chuang SS, Coupland SE, Czader M, Dave SS, de Jong D, Di Napoli A, Du MQ, Elenitoba-Johnson KS, Ferry J, Geyer J, Gratzinger D, Guitart J, Gujral S, Harris M, Harrison CJ, Hartmann S, Hochhaus A, Jansen PM, Karube K, Kempf W, Khoury J, Kimura H, Klapper W, Kovach AE, Kumar S, Lazar AJ, Lazzi S, Leoncini L, Leung N, Leventaki V, Li XQ, Lim MS, Liu WP, Louissaint A Jr, Marcogliese A, Medeiros LJ, Michal M, Miranda RN, Mitteldorf C, Montes-Moreno S, Morice W, Nardi V, Naresh KN, Natkunam Y, Ng SB, Oschlies I, Ott G, Parrens M, Pulitzer M, Rajkumar SV, Rawstron AC, Rech K, Rosenwald A, Said J, Sarkozy C, Sayed S, Saygin C, Schuh A, Sewell W, Siebert R, Sohani AR, Suzuki R, Tooze R, Traverse-Glehen A, Vega F, Vergier B, Wechalekar AD, Wood B, Xerri L, Xiao W; International Agency for Research on Cancer/World Health Organization. Alaggio R, et al. Leukemia. 2023 Sep;37(9):1944-1951. doi: 10.1038/s41375-023-01962-5. Leukemia. 2023. PMID: 37468552 Free PMC article. No abstract available.

Abstract

We herein present an overview of the upcoming 5^th edition of the World Health Organization Classification of Haematolymphoid Tumours focussing on lymphoid neoplasms. Myeloid and histiocytic neoplasms will be presented in a separate accompanying article. Besides listing the entities of the classification, we highlight and explain changes from the revised 4^th edition. These include reorganization of entities by a hierarchical system as is adopted throughout the 5^th edition of the WHO classification of tumours of all organ systems, modification of nomenclature for some entities, revision of diagnostic criteria or subtypes, deletion of certain entities, and introduction of new entities, as well as inclusion of tumour-like lesions, mesenchymal lesions specific to lymph node and spleen, and germline predisposition syndromes associated with the lymphoid neoplasms.

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Comment in

ALK1-negative primary cutaneous anaplastic large cell lymphoma of the hand and wrist.
Reiser D, Szallasi A, Sagerfors M. Reiser D, et al. J Hand Surg Eur Vol. 2023 Mar;48(3):276-277. doi: 10.1177/17531934221150844. Epub 2023 Jan 28. J Hand Surg Eur Vol. 2023. PMID: 36708220 No abstract available.
Response to the Comments from the Groupe Francophone de Cytogénétique Hématologique (GFCH) on the 5th edition of the World Health Organization classification of haematolymphoid tumors.
Siebert R, Schuh A, Ott G, Cree IA, Du MQ, Ferry J, Hochhaus A, Naresh KN, Solary E, Khoury JD. Siebert R, et al. Leukemia. 2023 May;37(5):1170-1172. doi: 10.1038/s41375-023-01872-6. Epub 2023 Mar 27. Leukemia. 2023. PMID: 36973349 Free PMC article. No abstract available.

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The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms

Affiliations

The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms

Authors

Affiliations

Erratum in

Abstract

Comment in

References

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