The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms

Joseph D Khoury¹, Eric Solary², Oussama Abla³, Yassmine Akkari⁴, Rita Alaggio⁵, Jane F Apperley⁶, Rafael Bejar⁷, Emilio Berti⁸, Lambert Busque⁹, John K C Chan¹⁰, Weina Chen¹¹, Xueyan Chen¹², Wee-Joo Chng¹³, John K Choi¹⁴, Isabel Colmenero¹⁵, Sarah E Coupland¹⁶, Nicholas C P Cross¹⁷, Daphne De Jong¹⁸, M Tarek Elghetany¹⁹, Emiko Takahashi²⁰, Jean-Francois Emile²¹, Judith Ferry²², Linda Fogelstrand²³, Michaela Fontenay²⁴, Ulrich Germing²⁵, Sumeet Gujral²⁶, Torsten Haferlach²⁷, Claire Harrison²⁸, Jennelle C Hodge²⁹, Shimin Hu³⁰, Joop H Jansen³¹, Rashmi Kanagal-Shamanna³⁰, Hagop M Kantarjian³², Christian P Kratz³³, Xiao-Qiu Li³⁴, Megan S Lim³⁵, Keith Loeb³⁶, Sanam Loghavi³⁰, Andrea Marcogliese¹⁹, Soheil Meshinchi³⁷, Phillip Michaels³⁸, Kikkeri N Naresh³⁶, Yasodha Natkunam³⁹, Reza Nejati⁴⁰, German Ott⁴¹, Eric Padron⁴², Keyur P Patel³⁰, Nikhil Patkar⁴³, Jennifer Picarsic⁴⁴, Uwe Platzbecker⁴⁵, Irene Roberts⁴⁶, Anna Schuh⁴⁷, William Sewell⁴⁸, Reiner Siebert⁴⁹, Prashant Tembhare⁴³, Jeffrey Tyner⁵⁰, Srdan Verstovsek³², Wei Wang³⁰, Brent Wood⁵¹, Wenbin Xiao⁵², Cecilia Yeung³⁶, Andreas Hochhaus⁵³

Affiliations

¹ Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jkhoury@unmc.edu.
² Department of Hematology, Gustave Roussy Cancer Center, Université Paris-Saclay, Villejuif, France. eric.solary@gustaveroussy.fr.
³ Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada.
⁴ The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
⁵ Pathology Unit, Department of Laboratories, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy.
⁶ Centre for Haematology, Imperial College London, London, UK.
⁷ Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
⁸ University of Milan, Fondazione Cà Granda, IRCCS, Ospedale Maggiore Policlinico, Milano, Italy.
⁹ Service d'hématologie, oncologie et transplantation, Hôpital Maisonneuve-Rosemont, Université de Montréal, Montréal, QC, Canada.
¹⁰ Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong.
¹¹ Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
¹² Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
¹³ Department of Hematology-Oncology, National University Cancer Institute, Singapore, Singapore.
¹⁴ Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL, USA.
¹⁵ Department of Pathology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
¹⁶ Liverpool Clinical Laboratories, Liverpool University Hospitals Foundation Trust, Liverpool, UK.
¹⁷ Faculty of Medicine, University of Southampton, Southampton, UK.
¹⁸ Amsterdam UMC, Location Vrije Universiteit Amsterdam, Department of Pathology, Amsterdam, The Netherlands.
¹⁹ Department of Pathology & Immunology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.
²⁰ Department of Pathology, Aichi Medical University Hospital, Nagakute, Japan.
²¹ Department of Pathology, Ambroise Pare Hospital, AP-HP and Versailles SQY University, Boulogne, France.
²² Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
²³ Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg and Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden.
²⁴ Laboratory of Hematology, Assistance Publique-Hôpitaux de Paris, Cochin Hospital and Université Paris Cité, CNRS, INSERM, Cochin Institute, Paris, France.
²⁵ Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University, Düsseldorf, Germany.
²⁶ Department of Pathology, Tata Memorial Hospital, Mumbai, India.
²⁷ MLL Munich Leukemia Laboratory, Munich, Germany.
²⁸ Department of Haematology, Guys and St Thomas' NHS Foundation Trust, London, UK.
²⁹ Indiana University School of Medicine, Indianapolis, IN, USA.
³⁰ Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
³¹ Lab Hematology, Dept LABGK, Radboud University Medical Center, Nijmegen, The Netherlands.
³² Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
³³ Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.
³⁴ Departments of Pathology and Oncology, Fudan University, Shanghai, China.
³⁵ Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
³⁶ Section of Pathology, Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
³⁷ Pediatric Hematology and Oncology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
³⁸ Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
³⁹ Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
⁴⁰ Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA, USA.
⁴¹ Department of Clinical Pathology, Robert-Bosch-Krankenhaus, and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.
⁴² Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
⁴³ Hematopathology Laboratory, Tata Memorial Hospital, Mumbai, India.
⁴⁴ Pathology and Lab Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
⁴⁵ Department of Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany.
⁴⁶ Department of Paediatrics, University of Oxford, Oxford, UK.
⁴⁷ Department of Oncology, University of Oxford, Oxford, UK.
⁴⁸ Immunology Division, Garvan Institute of Medical Research, Sydney, Australia.
⁴⁹ Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany.
⁵⁰ Cell, Developmental & Cancer Biology Department, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
⁵¹ Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.
⁵² Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
⁵³ Hematology/Oncology, Universitätsklinikum Jena, Jena, Germany. andreas.hochhaus@med.uni-jena.de.

PMID: 35732831
PMCID: PMC9252913
DOI: 10.1038/s41375-022-01613-1

Review

The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms

Joseph D Khoury et al. Leukemia. 2022 Jul.

. 2022 Jul;36(7):1703-1719.

doi: 10.1038/s41375-022-01613-1. Epub 2022 Jun 22.

Authors

Affiliations

¹ Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jkhoury@unmc.edu.
² Department of Hematology, Gustave Roussy Cancer Center, Université Paris-Saclay, Villejuif, France. eric.solary@gustaveroussy.fr.
³ Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada.
⁴ The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
⁵ Pathology Unit, Department of Laboratories, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy.
⁶ Centre for Haematology, Imperial College London, London, UK.
⁷ Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
⁸ University of Milan, Fondazione Cà Granda, IRCCS, Ospedale Maggiore Policlinico, Milano, Italy.
⁹ Service d'hématologie, oncologie et transplantation, Hôpital Maisonneuve-Rosemont, Université de Montréal, Montréal, QC, Canada.
¹⁰ Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong.
¹¹ Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
¹² Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
¹³ Department of Hematology-Oncology, National University Cancer Institute, Singapore, Singapore.
¹⁴ Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL, USA.
¹⁵ Department of Pathology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
¹⁶ Liverpool Clinical Laboratories, Liverpool University Hospitals Foundation Trust, Liverpool, UK.
¹⁷ Faculty of Medicine, University of Southampton, Southampton, UK.
¹⁸ Amsterdam UMC, Location Vrije Universiteit Amsterdam, Department of Pathology, Amsterdam, The Netherlands.
¹⁹ Department of Pathology & Immunology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.
²⁰ Department of Pathology, Aichi Medical University Hospital, Nagakute, Japan.
²¹ Department of Pathology, Ambroise Pare Hospital, AP-HP and Versailles SQY University, Boulogne, France.
²² Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
²³ Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg and Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden.
²⁴ Laboratory of Hematology, Assistance Publique-Hôpitaux de Paris, Cochin Hospital and Université Paris Cité, CNRS, INSERM, Cochin Institute, Paris, France.
²⁵ Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University, Düsseldorf, Germany.
²⁶ Department of Pathology, Tata Memorial Hospital, Mumbai, India.
²⁷ MLL Munich Leukemia Laboratory, Munich, Germany.
²⁸ Department of Haematology, Guys and St Thomas' NHS Foundation Trust, London, UK.
²⁹ Indiana University School of Medicine, Indianapolis, IN, USA.
³⁰ Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
³¹ Lab Hematology, Dept LABGK, Radboud University Medical Center, Nijmegen, The Netherlands.
³² Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
³³ Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.
³⁴ Departments of Pathology and Oncology, Fudan University, Shanghai, China.
³⁵ Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
³⁶ Section of Pathology, Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
³⁷ Pediatric Hematology and Oncology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
³⁸ Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
³⁹ Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
⁴⁰ Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA, USA.
⁴¹ Department of Clinical Pathology, Robert-Bosch-Krankenhaus, and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.
⁴² Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
⁴³ Hematopathology Laboratory, Tata Memorial Hospital, Mumbai, India.
⁴⁴ Pathology and Lab Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
⁴⁵ Department of Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany.
⁴⁶ Department of Paediatrics, University of Oxford, Oxford, UK.
⁴⁷ Department of Oncology, University of Oxford, Oxford, UK.
⁴⁸ Immunology Division, Garvan Institute of Medical Research, Sydney, Australia.
⁴⁹ Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany.
⁵⁰ Cell, Developmental & Cancer Biology Department, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
⁵¹ Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.
⁵² Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
⁵³ Hematology/Oncology, Universitätsklinikum Jena, Jena, Germany. andreas.hochhaus@med.uni-jena.de.

PMID: 35732831
PMCID: PMC9252913
DOI: 10.1038/s41375-022-01613-1

Abstract

The upcoming 5th edition of the World Health Organization (WHO) Classification of Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers arising in various organ systems within a single relational database. This paper summarizes the new WHO classification scheme for myeloid and histiocytic/dendritic neoplasms and provides an overview of the principles and rationale underpinning changes from the prior edition. The definition and diagnosis of disease types continues to be based on multiple clinicopathologic parameters, but with refinement of diagnostic criteria and emphasis on therapeutically and/or prognostically actionable biomarkers. While a genetic basis for defining diseases is sought where possible, the classification strives to keep practical worldwide applicability in perspective. The result is an enhanced, contemporary, evidence-based classification of myeloid and histiocytic/dendritic neoplasms, rooted in molecular biology and an organizational structure that permits future scalability as new discoveries continue to inexorably inform future editions.

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Conflict of interest statement

All authors underwent IARC clearance for potential conflicts of interest regarding this work.

Comment in

Response to the Comments from the Groupe Francophone de Cytogénétique Hématologique (GFCH) on the 5th edition of the World Health Organization classification of haematolymphoid tumors.
Siebert R, Schuh A, Ott G, Cree IA, Du MQ, Ferry J, Hochhaus A, Naresh KN, Solary E, Khoury JD. Siebert R, et al. Leukemia. 2023 May;37(5):1170-1172. doi: 10.1038/s41375-023-01872-6. Epub 2023 Mar 27. Leukemia. 2023. PMID: 36973349 Free PMC article. No abstract available.

References

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The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms

Affiliations

The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms

Authors

Affiliations

Abstract

Conflict of interest statement

Comment in

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical