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Editorial
. 2022 Jul;48(7):926-929.
doi: 10.1007/s00134-022-06751-9. Epub 2022 Jun 22.

Precision medicine for corticotherapy in COVID-19

Djillali Annane  1 , Gianfranco Umberto Meduri  2   3
Affiliations
Editorial

Precision medicine for corticotherapy in COVID-19

Djillali Annane et al. Intensive Care Med. 2022 Jul.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Da and GUM have no financial conflict of interest in relation to this topic.

Figures

Fig. 1
Fig. 1
Corticotherapy for acute illnesses today and tomorrow. Panel A Close monitoring of clinical response and markers of systemic inflammation (i.e., c-reactive protein, ferritin) should guide the adjustment of dose and duration of treatment. Panel B Precision medicine will consist of moving from rough clinical phenotypes to enriched endotypes from multi-biological, and imaging approaches, enabling to discriminate patients with hyper versus hypo-inflammatory status and those with intact versus altered corticosteroid signaling pathways. Then, for those eligible for corticotherapy, strategies based on nanomaterials encapsulating corticosteroids will allow finetuning drug delivery to specific tissue/cell targets
See this image and copyright information in PMC

Comment on

  • Major candidate variables to guide personalised treatment with steroids in critically ill patients with COVID-19: CIBERESUCICOVID study.
    Torres A, Motos A, Cillóniz C, Ceccato A, Fernández-Barat L, Gabarrús A, Bermejo-Martin J, Ferrer R, Riera J, Pérez-Arnal R, García-Gasulla D, Peñuelas O, Lorente JÁ, de Gonzalo-Calvo D, Almansa R, Menéndez R, Palomeque A, Villar RA, Añón JM, Balan Mariño A, Barberà C, Barberán J, Blandino Ortiz A, Boado MV, Bustamante-Munguira E, Caballero J, Cantón-Bulnes ML, Carbajales Pérez C, Carbonell N, Catalán-González M, de Frutos R, Franco N, Galbán C, Gumucio-Sanguino VD, de la Torre MDC, Díaz E, Estella Á, Gallego E, García Garmendia JL, Gómez JM, Huerta A, García RNJ, Loza-Vázquez A, Marin-Corral J, Martin Delgado MC, Martínez de la Gándara A, Martínez Varela I, López Messa J, Albaiceta GM, Nieto M, Novo MA, Peñasco Y, Pérez-García F, Pozo-Laderas JC, Ricart P, Sagredo V, Sánchez-Miralles A, Sancho Chinesta S, Serra-Fortuny M, Socias L, Solé-Violan J, Suarez-Sipmann F, Tamayo Lomas L, Trenado J, Úbeda A, Valdivia LJ, Vidal P, Barbé F; CIBERESUCICOVID Project Investigators. Torres A, et al. Intensive Care Med. 2022 Jul;48(7):850-864. doi: 10.1007/s00134-022-06726-w. Epub 2022 Jun 21. Intensive Care Med. 2022. PMID: 35727348 Free PMC article.

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