Editorial: The Molecular Basis of Somatic Evolution

Qiyuan Li^{1

2

3}, Bing Xu^{1

4}, Zhanlong Shen^{5

6}

Affiliations

¹ Department of Hematology, The First Affiliated Hospital of Xiamen University and Institute of Hematology, School of Medicine, Xiamen University, Xiamen, China.
² National Institute for Data Science in Health and Medicine, Xiamen University, Xiamen, China.
³ School of Medicine, Xiamen University, Xiamen, China.
⁴ Department of Hematology, Key Laboratory of Xiamen for Diagnosis and Treatment of Hematological Malignancy, Xiamen, China.
⁵ Laboratory of Surgical Oncology, Peking University People's Hospital, Beijing, China.
⁶ Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Beijing, China.

PMID: 35734593
PMCID: PMC9207474
DOI: 10.3389/fonc.2022.906068

Editorial

Editorial: The Molecular Basis of Somatic Evolution

Qiyuan Li et al. Front Oncol. 2022.

. 2022 Jun 6:12:906068.

doi: 10.3389/fonc.2022.906068. eCollection 2022.

Authors

Qiyuan Li^{1

2

3}, Bing Xu^{1

4}, Zhanlong Shen^{5

6}

Affiliations

¹ Department of Hematology, The First Affiliated Hospital of Xiamen University and Institute of Hematology, School of Medicine, Xiamen University, Xiamen, China.
² National Institute for Data Science in Health and Medicine, Xiamen University, Xiamen, China.
³ School of Medicine, Xiamen University, Xiamen, China.
⁴ Department of Hematology, Key Laboratory of Xiamen for Diagnosis and Treatment of Hematological Malignancy, Xiamen, China.
⁵ Laboratory of Surgical Oncology, Peking University People's Hospital, Beijing, China.
⁶ Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Beijing, China.

PMID: 35734593
PMCID: PMC9207474
DOI: 10.3389/fonc.2022.906068

No abstract available

Keywords: cancer; driver gene; intratumor heterogeneity (ITH); mutational signature; somatic evolution.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Comment on

Editorial on the Research Topic The Molecular Basis of Somatic Evolution

References

1. McGranahan N, Swanton C. Biological and Therapeutic Impact of Intratumor Heterogeneity in Cancer Evolution. Cancer Cell (2015) 27:15–26. doi: 10.1016/j.ccell.2014.12.001 - DOI - PubMed
1. Persi E, Wolf Y, Horn D, Ruppin E, Demichelis F, Gatenby R, et al. . Mutation-Selection Balance and Compensatory Mechanisms in Tumour Evolution. Nat Rev Genet (2021) 22:251–62. doi: 10.1038/s41576-020-00299-4 - DOI - PubMed
1. Koh G, Degasperi A, Zou X, Momen S, Nik-Zainal S. Mutational Signatures: Emerging Concepts, Caveats and Clinical Applications. Nat Rev Cancer (2021) 21:619–37. doi: 10.1038/s41568-021-00377-7 - DOI - PubMed
1. Guo J, Zhou Y, Xu C, Chen Q, Sztupinszki Z, Börcsök J, et al. . Genetic Determinants of Somatic Selection of Mutational Processes in 3,566 Human Cancers. Cancer Res (2021) 81:4205–17. doi: 10.1158/0008-5472.Can-21-0086 - DOI - PMC - PubMed
1. Helleday T, Eshtad S, Nik-Zainal S. Mechanisms Underlying Mutational Signatures in Human Cancers. Nat Rev Genet (2014) 15:585–98. doi: 10.1038/nrg3729 - DOI - PMC - PubMed

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Editorial: The Molecular Basis of Somatic Evolution

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Editorial: The Molecular Basis of Somatic Evolution

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