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. 2022 May 20:78:103832.
doi: 10.1016/j.amsu.2022.103832. eCollection 2022 Jun.

The effect of epinephrine and methylprednisolone on cardiac arrest patients

Hooman Rafiei  1   2 , Nasrin Bahrami  3 , Amir Hossein Meisami  1 , Haniyeh Azadifar  2 , Shahrouz Tabrizi  1
Affiliations

The effect of epinephrine and methylprednisolone on cardiac arrest patients

Hooman Rafiei et al. Ann Med Surg (Lond). .

Abstract

Background: Cardiopulmonary resuscitation (CPR) involves organized procedures performed on patients with cardiac arrest. CPR method and techniques can determine neurological outcomes of the patients. The aim of this study is to investigate the effect of epinephrine in combination with methylprednisolone on neurological complications and the need for vasopressor after resuscitation in patients with cardiac and respiratory arrest.

Methods: In this randomized control clinical trial, patients referred to (XXX) who suffered from cardiac arrest and required CPR were included. Patients were divided into two groups; intervention (methylprednisolone + epinephrine) and placebo (epinephrine + placebo). Patients' information was completed in a questionnaire based on demographic information, main objectives and important variables (neurological complication and the need for vasopressor) and SPSSv21 was used for statistical analysis.

Results: A total of 347 patients were included in the study. The intervention and control group were not significantly different in terms of gender, age systolic and diastolic blood pressure, p > 0.05. CPC scores were also not significantly different among the two groups, p > 0.05.131 patients (37.8%) needed vasopressor after the intervention and 216 patients (62.2%) did not need vasopressor. The two groups were significantly different in terms of intervention (P = 0.021).

Conclusion: Glucocorticoid, methylprednisolone does not reduce the risk of neurological complications following CPR in cardiac arrest patients.

Keywords: CPR; CPR, Cardiopulmonary resuscitation; Cardiac arrest; Epinephrine; Methylprednisolone; Neurological; ROSC, return of spontaneous circulation.

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