Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 May 18:78:103825.
doi: 10.1016/j.amsu.2022.103825. eCollection 2022 Jun.

A rare case of breast squamous cell carcinoma and literature review

Bhirrinta Varughese  1 , Siti Zubaidah Sharif  1 , Ho Kah Yee  1 , Nik Amin Sahid Nik Lah  2
Affiliations
Case Reports

A rare case of breast squamous cell carcinoma and literature review

Bhirrinta Varughese et al. Ann Med Surg (Lond). .

Abstract

Introduction: Breast Squamous Cell Carcinoma (SCC) is quite a rare tumour that the features portray squamous cell differentiation.

Presentation of case: We report a case of a 56-year-old female presented left breast lump that had been increasing in size for a 7 months duration associated with nipple retraction for one week. Ultrasound breast was done and revealed a large mixed echo density mass lesion in the left breast at 12 o'clock, 2cm from the nipple and measuring 4.2 × 3.4cm along with an enlarged node in the left axilla with thickened cortex and as for Mammogram revealed suspicious left breast lesion with enlarged axillary nodes, BIRADS 5. Histopathology from the left breast showed Invasive carcinoma with squamous differentiation, B5b, ER: negative, PR: Positive, Her2: Negative, CK5/6: Positive. Then a staging CECT Thorax, Abdomen and Pelvis was done which showed enhancing mass lesion seen at the left breast (4.1 × 4.3cm) with areas of necrosis within and multiple enlarged left axillary nodes seen with no local infiltration to the muscle or skin as well as no distant metastases. Patient underwent Neoadjuvant chemotherapy for 6 cycles and completed them.

Discussion: This case highlights the crucial need of early detection along with the obstacles faced in reaching an early diagnosis tagged with the lack of guideline to manage this patient.

Conclusion: In the management of Breast Squamous Cell Carcinoma, the standard treatment would be to go for mastectomy with axillary clearance. However, the prognosis usually depends on the tumour size and the advance age of the patient as described in this article.

Keywords: Breast cancer, squamous,, metaplastic.

PubMed Disclaimer

Conflict of interest statement

All authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
(Mammogram image, tumor showed with white arrow).
See this image and copyright information in PMC

References

    1. Yadav S., Yadav D., Zakalik D. Squamous cell carcinoma of the breast in the United States: incidence, demographics, tumor characteristics, and survival. Breast Cancer Res. Treat. 2017;164(1):201–208. - PubMed
    1. Behranwala K.A., Nasiri N., Abdullah N., Trott P.A., Gui G.P.H. Squamous cell carcinoma of the breast: clinico-pathologic implications and outcome. Eur. J. Surg. Oncol. 2003;29(4):386–389. - PubMed
    1. Zhang X., Zhang B., Zang F., Zhao L., Yuan Z., Wang P. Clinical features and treatment of squamous cell carcinoma of the breast. OncoTargets Ther. 2016;9:3181–3185. - PMC - PubMed
    1. Grenier J., Soria J.C., Mathieu M.C., Andre F., Abdelmoula S., Velasco V., et al. Differential immunohistochemical and biological profile of squamous cell carcinoma of the breast. Anticancer Res. 2007;27(1 B):547–555. - PubMed
    1. Aparicio I., Martínez A., Hernández G., Hardisson D., De Santiago J. Squamous cell carcinoma of the breast. Eur. J. Obstet. Gynecol. Reprod. Biol. 2008;137(2):222–226. - PubMed

Publication types